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Episode
I’ve Found the Best Way to Beat Insulin Resistance - and it’s shockingly simple
~46 min
Episode Brief·YouTube

I’ve Found the Best Way to Beat Insulin Resistance - and it’s shockingly simple

Thomas DeLauer
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TL;DR

The four things you'd lose by not watching

4 items

TL;DR

The four things you'd lose by not watching

4 items
1

Thomas DeLauer frames insulin resistance as an inflammatory problem, not a carbohydrate problem, and argues for a carb-cycling approach that maintains glucose tolerance rather than eliminating carbs entirely.

2

The carb-cycling protocol is split into three daily activity levels: low activity (low-carb, high-protein, moderate fat), moderate activity like resistance training (resistant starches such as cooled potatoes/oats plus CoQ10, alpha-lipoic acid, berberine), and high-intensity days (some starchy carbs like rice). Maximum 4 higher-carb days per week.

3

Carb timing depends on overall daily activity, not just workouts: active individuals (>10,000 steps) should eat carbs earlier in the day; sedentary individuals should save carbs for the evening when they are naturally more active at home.

4

Even minimal muscular contraction dramatically improves glucose uptake: a study showed that 30 isometric leg presses per day during bed rest led to a 30% increase in glucose transporters, versus a 19% drop with complete inactivity.

Protocols

Concrete recipes — what, when, how much, and why

3 items

Carbohydrate Timing by Overall Daily Activity

WhatTime carbohydrate intake based on your daily movement level: if you are active all day (e.g., >10k steps), eat carbs earlier; if you are sedentary during the day, save carbs for the evening.
WhenEvery day, independent of workout time.
DoseActive: consume carbohydrates with earlier meals. Sedentary: keep meals low-carb/high-protein through the day, eat carbs with dinner or later. Not a precise gram count.
For whomAnyone with insulin resistance or metabolic concerns, especially those with desk jobs.
WhyWhen you move, muscles take up glucose through insulin-independent pathways, so carbs are handled better during activity windows. Sedentary people tend to become more active after work, making evening a superior carbohydrate window.
CaveatsDo not get hung up on peri-workout carb timing; total daily activity pattern matters more for insulin resistance. The advice is a guideline, not an absolute rule.

Thomas acknowledges that conventional wisdom says to eat carbs around workouts, but he argues that for resolving insulin resistance, the bigger picture is daily activity level. He uses the leg press isometrics study to underscore how even tiny amounts of contraction massively increase glucose uptake. Sedentary individuals often sit all day and then become moderately active at home, making evening a better time. Conversely, a person on their feet all day (waiter, construction) can handle carbs throughout the day. He also hints at potential sleep benefits from evening carbs for those who are otherwise low-carb all day, but does not expand on that. This timing method dovetails with the carb cycling protocol to further optimize glucose tolerance.

Mechanism

Insulin-independent glucose uptake: contracting muscles can absorb glucose without needing insulin. So when you are on your feet moving, you get a 'mechanical suck-up' of carbs. If you are sedentary, giving carbs when you aren't moving leads to poor uptake and higher insulin demand, worsening insulin resistance. By delaying carbs to the evening when you are naturally more active (household chores, family activities), you align ingestion with periods of higher glucose disposal capacity. For active all-day people, spreading carbs early capitalizes on continuous low-grade movement to clear glucose.

If you are sedentary, it is more ideal to keep it low carb and high protein throughout the course of the day and actually have your carbohydrates allocated to the end of the day because you're not active.

Also said
“When you are moving your body, the cells have the ability to soak up glucose even if insulin is not present. Right? So that means that if you are moving around, even if you're insulin resistant, the carbs that you eat are going to get soaked up through a mechanical sort of suckup of the carbs.”— Explains the underlying mechanism in simple terms.
“Do not worry about timing your carbohydrates surrounding your workout too much. Yes, it matters if you're an athlete. ... But if you're looking at insulin resistance, do not get hung up on that.”— Clarifies that peri-workout timing is not the key factor here.

Daily Isometric Contractions to Boost Glucose Uptake

WhatPerform a short bout of isometric exercises (e.g., 30 isometric leg presses) daily to dramatically improve glucose transporter activity and insulin-independent glucose uptake.
WhenDaily, particularly for sedentary individuals. Could be done in the morning or whenever convenient.
DoseRoughly 10 minutes; 30 isometric reps (pushing against resistance without full movement).
For whomEveryone, especially those with insulin resistance or limited mobility, and those who want to support glucose handling with minimal time investment.
WhyA study found that bed-rest subjects doing only this had a 30% increase in glucose translocation, while inactive subjects saw a 19% loss, proving profound metabolic benefits from minimal static muscle contraction.
CaveatsThe study used leg press, but the principle generalizes to any isometric hold that engages large muscle groups. Always ensure proper form and safety, particularly if deconditioned.

Thomas uses this study from the Journal of Applied Physiology to hammer home that activity—no matter how small—is a powerful lever for insulin resistance. The protocol is less about building muscle or strength and more about creating a daily metabolic signal. He implies that people who want to experiment with carbohydrate timing or who are unsure about their carb allocation can use this simple practice as a safety net, ensuring their cells are primed to take up glucose. He frames it as a kind of 'free ride' to handle carbs better, encouraging listeners to incorporate very brief, low-effort isometrics into their routine. The dramatic numerical contrast (30% increase vs. 19% decrease) serves as a memorable anchor for the importance of daily movement.

Mechanism

Muscle contraction of any kind, including isometric holds, stimulates the translocation of GLUT4 glucose transporters to the cell surface independent of insulin. This means the muscle cells literally 'suck up' glucose from the blood. The study highlighted by Thomas showed that even without full range-of-motion resistance exercise, the isometric contraction signal was sufficient to upregulate these transporters and improve glucose metabolism, contrasting sharply with complete immobilization which caused rapid transporter loss.

the people that were on bed rest but did just these 30 isometrics which would probably take 10 minutes. They had a 30% increase in the glucose transllocation in the glue uh glute for transllocation the ability to suck glucose up.

Also said
“The people that were only bed rest had a 19% reduction in glucose transporters that would bring glucose in in the cell.”— Provides the startling baseline deterioration that the isometrics reversed.
“even a little bit of activity encourages the utilization of glucose.”— Concise summary of the entire segment's message.

Supplement Stack for Carb Cycling Days

WhatOn moderate carb cycling days, add coenzyme Q10, alpha-lipoic acid, and berberine to support carbohydrate utilization and metabolic efficiency.
WhenOn days classified as moderate activity (resistance training, etc.) when consuming resistant starches.
DoseNot specified; use standard label doses.
For whomIndividuals practicing carb cycling for insulin resistance, especially on moderate activity days.
WhyThese compounds act as metabolic precursors and sensitizers that can help the body utilize carbohydrates more efficiently and mitigate glucose spikes.
CaveatsThomas does not cite specific studies for these supplements in this video; he simply recommends them. Users should check for personal tolerance and interactions. Not a replacement for diet and activity.

Thomas mentions these supplements specifically in the context of moderate carb cycling days, not as a daily blanket recommendation. He positions them as adjuncts that 'help with precursors' and enable more efficient carbohydrate utilization. He does not delve into the science of each here, but he has covered them elsewhere. The inclusion of berberine is particularly notable because it's often used as a natural metformin alternative, fitting the insulin resistance theme. This brief protocol integrates supplementation into the broader strategy, giving advanced followers an extra layer of optimization.

Mechanism

Coenzyme Q10 supports mitochondrial electron transport and ATP production, potentially improving cellular energy metabolism. Alpha-lipoic acid is an antioxidant that can enhance insulin sensitivity and glucose uptake. Berberine activates AMPK (a metabolic master switch) and has been shown to lower blood glucose by improving insulin sensitivity and reducing hepatic glucose production. By combining these on days when carbohydrates are introduced via resistant starches, the aim is to maximize the metabolic machinery that processes those carbs, reducing the glycemic impact and supporting the cell's ability to welcome glucose.

I would recommend on the days where you're carb cycling and things like this is add in things like co-enzyme Q10, add in things like alphaloic acid. These can help with these precursors that might even help you utilize these carbohydrates a little bit more efficiently. You can also add something in like bourberine on these days.

What's new

Personal practice updates, fresh positions, predictions

4 items

Insulin resistance is fundamentally inflammatory, not a carbohydrate problem

beginning

Thomas repositions insulin resistance as an inflammatory issue that secondarily impairs carbohydrate utilization, challenging the common narrative that carbs are the root cause.

Why this matters: It shifts the focus from carbohydrate avoidance to restoring metabolic flexibility and glucose tolerance through strategic exposure and activity.

Background

Mainstream advice often tells people with insulin resistance to simply cut carbs, but Thomas argues this overlooks the need to retrain the body's systems.

Thomas explains that the goal is not to drain the body's ability to use carbs but to get the body better at using them. He acknowledges that reducing carb intake is often a first step, but emphasizes that insulin resistance is an inflammatory issue manifesting as poor carb handling. Therefore, the strategy should be to calm inflammation while reintroducing carbs in a way that encourages proper utilization. This includes using carb cycling, resistant starches, and activity-timed intake to rebuild glucose tolerance rather than permanently avoiding carbohydrates. He contrasts this with high-fat, very low-carb approaches, warning that high amounts of saturated fat can still contribute to insulin resistance unless the diet is extremely low in carbs (like carnivore).

insulin resistance is not necessarily a problem with carbohydrates, per se. It's an inflammatory issue that manifests in the improper utilization of carbohydrates.

Also said
“you want to get your body better at using carbohydrates. Remember that insulin resistance is not necessarily a problem with carbohydrates, per se.”— Reinforces the core concept of improving the body's carbohydrate handling rather than abstaining.
“high amounts of saturated fat, unless you're doing something like carnivore or very low carb, where that's really the only fats that are coming in, the fats can still contribute to insulin resistance, right?”— Counters the idea that going high-fat is a solution by highlighting fat's potential role in insulin resistance.

Resistance training is not a high-intensity activity that burns many carbs

early

Thomas debunks the myth that resistance training is a high-intensity, carbohydrate-depleting activity, stating it burns few calories and carbohydrates unless training extremely hard.

Why this matters: This misconception often leads people to over-consume carbs on lifting days, when they should instead treat them as moderate days with resistant starches.

Background

Many fitness enthusiasts classify weight training as 'anaerobic' and assume it needs a high carbohydrate intake for fuel and recovery.

Thomas clarifies that resistance training does not burn a ton of calories or utilize a ton of carbohydrates unless the intensity is very high. He notes that many people talk about it as if it were black and white, but the average resistance session is moderate in terms of metabolic demand. Therefore, he places resistance training in the 'moderate activity' category for carb cycling, where one should consume resistant starches rather than simple starchy carbs. He specifically suggests resistant starches like potatoes that have been heated and then cooled, or oats that have been cooked and cooled, as these turn into more of a fiber and elicit a lower glucose response while still training the body's systems.

resistance training is not super high intensity and that's a big big myth that needs to be debunked okay a lot of people talk about it as it's as it's anorobic so it's black and white it's intense resistance training doesn't burn a ton of calories and it doesn't utilize a ton of carbohydrates unless you're really training hard.

Also said
“Resistance training days, moderate activity days are days where you would want to carb cycle with more resistant starches.”— Directly links the myth correction to a specific dietary protocol.

Sedentary individuals should eat carbs in the evening, not earlier

mid

Contrary to conventional advice, Thomas argues that if you are sedentary during the day, you should save your carbohydrate intake for the evening when you are likely more active at home.

Why this matters: It flips the 'no carbs at night' rule and uses real-world activity patterns to justify evening carbohydrate consumption for better glucose handling.

Background

Standard diet advice often warns against eating carbs late in the day, citing concerns about sleep, fat storage, and lower insulin sensitivity at night.

Thomas bases this recommendation on the principle of insulin-independent glucose uptake. When a person is moving, muscle cells can take up glucose without insulin, so consuming carbs during periods of relative inactivity leads to poor handling. He points out that a sedentary office worker is actually more active after leaving work—doing laundry, playing with kids, cooking dinner—so evening becomes a window of higher movement. Therefore, holding off on carbs until later in the day can improve their disposal. Additionally, he suggests this may even provide a sleep benefit, and he explicitly advises against obsessing over peri-workout carb timing for insulin resistance, as total daily activity matters more. He contrasts this with someone who is active all day (e.g., a waiter, construction worker): those individuals benefit from having carbs earlier to spread the glucose load throughout the day.

If you are sedentary, it is more ideal to keep it low carb and high protein throughout the course of the day and actually have your carbohydrates allocated to the end of the day because you're not active.

Also said
“you go home, you might be more active. You might be doing some laundry. You might be playing with the kids. You might be cooking dinner. You're likely more active at home than you were throughout the course of the day. Meaning you're in a better spot to consume those carbohydrates then, independent of whenever your workout is.”— Provides the behavioral reasoning behind the timing advice.

Just 30 isometric leg presses dramatically increase glucose uptake even without full movement

later

Thomas highlights a study where bed-rest subjects who performed only 30 isometric leg presses daily saw a 30% increase in glucose transporter translocation, versus a 19% drop without the isometrics.

Why this matters: It showcases how extremely minimal activity can profoundly affect glucose metabolism, reinforcing the importance of even tiny movement snacks throughout the day.

Background

The prevailing belief is that significant exercise volume is required to improve metabolic health, but this study suggests isometric holds alone can be highly effective.

This finding comes from a study published in the Journal of Applied Physiology. Over 19 days of bed rest, one group did only 30 isometric leg press reps per session—essentially pushing against a lowered platform without performing full joint movements. The active group not only preserved but increased their glucose uptake capability by 30%, while the fully sedentary group lost 19% of their glucose transporters. Thomas uses this to emphasize that any muscular contraction, even static holds, triggers insulin-independent glucose uptake. He implies that incorporating brief isometric exercises could be a powerful, time-efficient tool for combating insulin resistance, and he ties it to the principle that activity at any level is the key to enabling the body to 'soak up' glucose without needing insulin.

The people that were on bed rest but did just these 30 isometrics which would probably take 10 minutes. They had a 30% increase in the glucose transllocation in the glue uh glute for transllocation the ability to suck glucose up.

Also said
“The people that were only bed rest had a 19% reduction in glucose transporters that would bring glucose in in the cell.”— Quantifies the negative effect of full inactivity, amplifying the benefit of the small intervention.

Recommendations

Products, supplements, and tools mentioned in the episode

4 items

Coenzyme Q10 (CoQ10)

Supplement

Recommended to be taken on moderate carb cycling days to aid carbohydrate utilization by supporting mitochondrial function.

Thomas suggests adding CoQ10 alongside alpha-lipoic acid and berberine on days where you consume resistant starches (moderate activity days). He frames these as 'precursors' that help the body use carbs more efficiently, though he does not elaborate on mechanism here. The recommendation is intended for those already following the carb cycling protocol.

add in things like co-enzyme Q10, add in things like alphaloic acid.

Find Coenzyme

Alpha-lipoic acid

Supplement

Recommended alongside CoQ10 and berberine on moderate carb cycling days to improve carbohydrate handling.

Alpha-lipoic acid is a well-known antioxidant and insulin sensitizer. Thomas groups it with CoQ10 as a helper for using carbs more efficiently. He provides no specific dose or brand, but positions it within the broader strategy of carb cycling to mitigate glucose responses.

add in things like alphaloic acid.

Find Alpha-lipoic

Berberine

Supplement

Suggested for moderate carb cycling days to enhance carbohydrate efficiency and support metabolic health.

Berberine is often compared to metformin for its glucose-lowering effects via AMPK activation. Thomas mentions it as an optional addition on days with resistant starches, implying it helps manage the glucose response from those carbohydrates. Again, no dosing details are given, but it is a targeted recommendation for insulin resistant individuals doing carb cycling.

You can also add something in like bourberine on these days.

Find Berberine

Resistant Starches (Cooled Potatoes and Oats)

Practice

Thomas recommends consuming resistant starches like potatoes that have been heated and then cooled, or oats that have been cooked and cooled, on moderate activity days.

He explains that when starchy foods like potatoes or oats are cooked and then cooled, they form retrograded starch, which behaves more like fiber in the body. This results in a lower glucose response while still engaging the body's carbohydrate processing pathways. He suggests this for days with resistance training or other moderate activity, as a bridge between low-carb days and high-starch days. It's a practical dietary hack to improve carb tolerance without spiking blood sugar.

you might want to bring things in like, for example, potatoes that have been heated and then cooled. Okay, these are a great example of resistant starches. Another example, even though I'm not personally a big fan of oatmeal, is going to be oats, right? You cook them and then you could cool them, put them in the fridge, and it becomes a resistant retrograded starch.

Also said
“What that means that the body doesn't utilize those carbs the same. They actually turn into more of a fiber.”— Explains the practical effect of retrogradation.
Find Resistant
Disclosed sponsorships1speaker disclosed

Subco App (subco.com/thomas)

Service Sponsored · disclosed

A free app that helps users manage supplement stacks and shop based on independent ratings considering oxidation, clinical studies, and other quality metrics.

DisclosureThomas provides a personalized referral link (subco.com/thomas), indicating a partnership, though he states the app's supplement ratings are independent and not bought by brands.

Thomas shares that he has entered his entire supplement stack into Subco and was happy with the ratings. The app's rating system evaluates supplements on factors like oxidation and the strength of clinical evidence, allowing users to make informed choices without brand bias. He emphasizes that Subco is not paid by supplement companies, so its ratings are objective. The app also lets users share their stacks so others can view them. Thomas promotes it as a tool that enhances his own regimen and can help listeners navigate the confusing supplement market. The personalized link suggests he may earn a commission or is an official partner.

Personal experience

I have my entire supplement stack in there. You can click on the link and actually check out my stack itself, too, which is pretty cool. ... I inputed my stack and I was pretty happy with all the ratings of the ones that I had already chosen.

It's a free app. So go ahead and check it out. That link is down below. It's subco.com/thomas.

Also said
“they're not bought and paid for by these. they're just doing the work with looking at clinicals, looking at oxidation, looking at all these things so that you can make the best, most informed decision.”— Highlights the app's value proposition of unbiased ratings.
Find Subco

Notable quotes

Lines worth pulling out — contrarian, specific, or perfectly phrased

5 items
insulin resistance is not necessarily a problem with carbohydrates, per se. It's an inflammatory issue that manifests in the improper utilization of carbohydrates.
Concise reframe that challenges the anti-carb dogma and sets up the entire video's philosophy.
resistance training is not super high intensity and that's a big big myth that needs to be debunked ... resistance training doesn't burn a ton of calories and it doesn't utilize a ton of carbohydrates unless you're really training hard.
A provocative correction of a common fitness assumption, directly impacting how people should structure their nutrition.
When you are moving your body, the cells have the ability to soak up glucose even if insulin is not present.
Captures the key physiological principle (insulin-independent uptake) in a vivid, accessible way.
The people that were on bed rest but did just these 30 isometrics which would probably take 10 minutes. They had a 30% increase in the glucose transllocation in the glue uh glute for transllocation the ability to suck glucose up.
Memorable statistic contrasting dramatic gain with tiny effort, emphasizing the power of minimal movement.
Stop the confusion about insulin resistance being a glucose problem and understand that this is a more fundamental inflammatory problem where glucose utilization and poor utilization is just a side effect.
Closing statement that encapsulates the video's core message, urging a shift in perspective.

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Topics covered

insulin-resistancecarb-cyclingglucose-toleranceinflammationresistant-starcheshigh-intensity-trainingcarbohydrate-timinginsulin-independent-glucose-uptakeisometric-exercisemitochondrial-densityprotein-intakefat-intakesaturated-fatcoenzyme-q10alpha-lipoic-acidberberinesubco-app
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Educational summary of the cited expert source — not medical advice. Open the source recording linked above and consult a qualified physician before acting on any protocol.