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Episode
The Highest Protein, Most Anti-Inflammatory Nut in the World has Been Discovered
~45 min
Episode Brief·YouTube

The Highest Protein, Most Anti-Inflammatory Nut in the World has Been Discovered

Thomas DeLauer
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TL;DR

The four things you'd lose by not watching

4 items

TL;DR

The four things you'd lose by not watching

4 items
1

Sacha inchi (Plukenetia volubilis) is claimed to be the highest-protein, highest-omega-3, and most anti-inflammatory nut/seed, with 47–48% protein and 44% omega-3 content.

2

Human and animal studies show sacha inchi oil blunts post-meal inflammatory markers (IL-6, LPS), improves insulin sensitivity, activates sirtuin-1, and upregulates PPAR-alpha for better fat oxidation.

3

The seed contains beta-sitosterol (joint anti-inflammatory), resveratrol (sirtuin activator), and other antioxidants that reduce oxidative stress even in skin.

4

Thomas DeLauer personally uses Brass Roots (Grassroots Foods) sacha inchi butter as a peanut-free, high-omega-3 alternative, and recommends consuming it earlier in the day to stabilize glucose and lipids.

Protocols

Concrete recipes — what, when, how much, and why

2 items

Consume sacha inchi earlier in the day for glucose and lipid stabilization

WhatEat sacha inchi seeds, oil, or butter in the morning or at lunch to help modulate blood glucose and lipids throughout the day.
WhenMorning or lunch, not right before bed.
DoseNot specified; a typical serving (e.g., 1-2 tablespoons of butter or a handful of seeds) is implied.
For whomAnyone looking to stabilize blood sugar and reduce post-meal inflammation, especially those with metabolic dysfunction.
WhyStudies show sacha inchi reduces post-meal glucose spikes and improves insulin sensitivity; consuming it earlier may provide day-long metabolic benefits.
CaveatsAvoid right before bed (no specific reason given, but likely due to its potential to increase energy/fat oxidation).

DeLauer suggests that because sacha inchi can blunt the glucose and inflammatory response to a high-carb meal, having it with breakfast or lunch could set a better metabolic tone for the day. He doesn't prescribe an exact dose but implies that regular inclusion is beneficial. The timing advice is based on the acute effects seen in studies where oil was consumed with a meal.

Mechanism

The oil's antioxidants and fatty acids slow gastric emptying, improve insulin signaling, and activate PPAR-alpha and sirtuin-1, leading to better glucose disposal and fat oxidation.

Maybe not something you want to have right before bed and still be fine. But having it in the morning or lunch could stabilize glucose and lipids throughout the day, helping you feel a little bit better and possibly even making you feel a little less inflamed.

Replace peanut or almond butter with sacha inchi butter

WhatUse sacha inchi butter as a direct substitute for peanut butter or almond butter in meals and snacks.
WhenAnytime you would normally use nut butter (e.g., on toast, in smoothies, for kids' lunches).
DoseAs desired; no specific limit.
For whomPeople with peanut or tree nut allergies, histamine intolerance, or anyone seeking a more anti-inflammatory nut/seed butter.
WhySacha inchi butter is allergy-friendly (tree nut and peanut-free), higher in omega-3, lower in omega-6, and contains probiotics. It avoids the high phytic acid and inflammatory omega-6s common in other nut butters.
CaveatsNone mentioned, but ensure the product is from a reputable source to avoid rancidity (high PUFA content).

DeLauer personally uses it because he has a histamine response to peanuts. He highlights that the Brass Roots sacha inchi butter is smooth, tasty, and fortified with probiotics, making it a superior choice for gut health. He also notes it's safe for school environments due to being free of common allergens.

Mechanism

The high omega-3 (alpha-linolenic acid) and low omega-6 ratio reduce inflammatory eicosanoid production. Probiotics support gut health, potentially reducing LPS translocation.

Personal experience

I can't have peanuts. I have a histamine response to peanuts. So, this has been a great replacement for me.

It's a really good way to just have an alternative, something that's a little bit better for you than the traditional kind of almond butter and peanut butter, which are super high in phytic acid and have a bunch of these omega sixs that are problematic.

Also said
“It's nice to have a nut butter or a seed butter that's a really high omega-3 and much more stable in that respect.”— Emphasizes the fatty acid stability advantage.

What's new

Personal practice updates, fresh positions, predictions

3 items

Sacha inchi oil blunts post-meal inflammation even in unhealthy individuals

A study in the Journal of Food Biochemistry showed that adding sacha inchi oil to a high-carb, high-saturated-fat breakfast reduced IL-6 and LPS in metabolically unhealthy people, and also lowered cholesterol spikes in healthy people.

Why this matters: It demonstrates that sacha inchi can mitigate the acute inflammatory response to a poor-quality meal, with effects on gene expression of inflammatory cytokines.

Background

Postprandial inflammation is a known contributor to chronic disease. Most interventions focus on chronic intake; this study shows acute protection.

The study compared 20 metabolically healthy and 22 metabolically unhealthy individuals. They consumed a high-carb, high-saturated-fat breakfast with or without sacha inchi oil. In healthy subjects, sacha inchi reversed the temporary rise in cholesterol and squashed IL-6. In unhealthy subjects, it reduced lipopolysaccharides (LPS) from gram-negative gut bacteria and decreased the gene expression of IL-6, meaning it turned down the genetic machinery for inflammation. DeLauer emphasizes that this isn't a license to eat junk, but it reveals potent anti-inflammatory mechanisms.

In the metabolically unhealthy people, it actually reduced lipopolysaccharides. It reduced the inflammatory response essentially resulting from compounds from gram negative bacteria in the gut.

Also said
“They had less of the actual genes after eating this meal which was really interesting.”— Highlights the gene-expression level effect, not just biomarker reduction.

Sacha inchi activates sirtuin-1 and improves mitochondrial fat oxidation

A study in Food & Function found that sacha inchi oil increased sirtuin-1 expression 4 hours after a meal, and another study showed it upregulates PPAR-alpha, enhancing mitochondrial fat burning and reducing leptin resistance.

Why this matters: Links sacha inchi to the longevity-associated sirtuin pathway (popularized by David Sinclair) and to direct metabolic improvements in fat utilization.

Background

Sirtuin-1 is a NAD+-dependent deacetylase linked to longevity and metabolic health. PPAR-alpha is a nuclear receptor that promotes fatty acid oxidation.

DeLauer explains that the high resveratrol content in sacha inchi likely activates sirtuin-1, similar to how resveratrol from grapes works. The PPAR-alpha upregulation makes mitochondria more efficient at using fats for fuel, which can increase satiety and reduce leptin resistance. This is not a weight-loss magic bullet but a fundamental improvement in metabolic flexibility. He ties this to the seed's overall antioxidant capacity, which supports cleaner energy production.

They had an increase in what's called certuin one expression... certuins... are good for longevity... and it's really good from a longevity perspective and this probably has to do with the fact that satcha and seeds are quite high in resveratrol.

Also said
“It makes the mitochondria more efficient and have a stronger affinity for fats. So, it makes it want to burn fats more.”— Simplifies the PPAR-alpha mechanism.

Sacha inchi improves insulin sensitivity at the pancreatic beta cell level

A study in Preventive Nutrition and Food Science found that sacha inchi oil improved insulin sensitivity and increased expression of insulin signaling proteins in pancreatic beta cells.

Why this matters: Goes beyond typical insulin sensitizers by showing a direct effect on the insulin-producing cells themselves.

Background

Most dietary interventions improve insulin sensitivity via muscle or liver; direct beta-cell effects are less common.

DeLauer presents this as part of the 'metabolic reboot' narrative. The study adds to the evidence that sacha inchi oil can lower post-meal glucose not just by slowing absorption (fat effect) but by enhancing insulin action and possibly preserving beta-cell function. This is particularly relevant for those with metabolic dysfunction.

It improved insulin sensitivity but it also improved insulin sensitivity at the actual pancreatic beta cell level. and increase the expression of insulin signaling proteins.

Disclosed sponsorships1speaker disclosed

Brass Roots (Grassroots Foods) Sacha Inchi Butter

Product Sponsored · disclosed

DeLauer recommends this specific brand of sacha inchi butter as a high-quality, probiotic-enriched alternative to common nut butters. He has used it personally for a long time.

DisclosureSpeaker provides discount code TD20 for 20% off at Grassroots Foods website.

The butter is made from sacha inchi seeds and includes added probiotics. DeLauer praises its smooth texture and taste, and notes it is allergy-safe (tree nut and peanut free). He suggests it's ideal for kids' lunches. The brand also sells whole seeds and other products. The discount code TD20 is offered at checkout on the Grassroots Foods website.

vs alternatives

Compared to almond and peanut butter, sacha inchi butter is higher in omega-3, lower in omega-6, lower in phytic acid, and free of common allergens. It also contains probiotics, which typical nut butters lack.

Personal experience

DeLauer states he has recommended Brass Roots for a long time and now uses their sacha inchi butter because he cannot eat peanuts due to histamine issues. He finds it a great replacement.

The satcha butter they also add probiotics to. So, you're getting the probiotics, you're getting a bunch of protein. It's the highest protein seed that's out there.

Also said
“That code TD20 gets you 20% off their website.”— Provides the specific discount code.
Find Brass

Notable quotes

Lines worth pulling out — contrarian, specific, or perfectly phrased

4 items
Probably the most anti-inflammatory nut or seed that's out there. Legit. It's also the highest protein seed or nut that's out there, too, which makes it even better.
Bold, superlative claim that sets the tone for the entire video.
They had less of the actual genes after eating this meal which was really interesting.
Highlights the gene-expression level impact, which is a deeper anti-inflammatory effect.
Satcha Ini is unique. Like, it stands in a league of its own, which is why we're seeing more and more research coming out.
Reinforces the exceptionalism of sacha inchi in the nut/seed category.
It's nice to have a nut butter or a seed butter that's a really high omega-3 and much more stable in that respect.
Practical endorsement of the butter as a healthier swap.

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Topics covered

sacha-inchianti-inflammatoryomega-3proteinmitochondrial-healthsirtuinsresveratrolinsulin-sensitivityjoint-healthbeta-sitosterolpostprandial-inflammationgut-healthallergy-friendlynut-butter-alternative
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Educational summary of the cited expert source — not medical advice. Open the source recording linked above and consult a qualified physician before acting on any protocol.