The Highest Protein, Most Anti-Inflammatory Nut in the World has Been Discovered

DeLauer suggests that because sacha inchi can blunt the glucose and inflammatory response to a high-carb meal, having it with breakfast or lunch could set a better metabolic tone for the day. He doesn't prescribe an exact dose but implies that regular inclusion is beneficial. The timing advice is based on the acute effects seen in studies where oil was consumed with a meal.

DeLauer personally uses it because he has a histamine response to peanuts. He highlights that the Brass Roots sacha inchi butter is smooth, tasty, and fortified with probiotics, making it a superior choice for gut health. He also notes it's safe for school environments due to being free of common allergens.

The study compared 20 metabolically healthy and 22 metabolically unhealthy individuals. They consumed a high-carb, high-saturated-fat breakfast with or without sacha inchi oil. In healthy subjects, sacha inchi reversed the temporary rise in cholesterol and squashed IL-6. In unhealthy subjects, it reduced lipopolysaccharides (LPS) from gram-negative gut bacteria and decreased the gene expression of IL-6, meaning it turned down the genetic machinery for inflammation. DeLauer emphasizes that this isn't a license to eat junk, but it reveals potent anti-inflammatory mechanisms.

DeLauer explains that the high resveratrol content in sacha inchi likely activates sirtuin-1, similar to how resveratrol from grapes works. The PPAR-alpha upregulation makes mitochondria more efficient at using fats for fuel, which can increase satiety and reduce leptin resistance. This is not a weight-loss magic bullet but a fundamental improvement in metabolic flexibility. He ties this to the seed's overall antioxidant capacity, which supports cleaner energy production.

DeLauer presents this as part of the 'metabolic reboot' narrative. The study adds to the evidence that sacha inchi oil can lower post-meal glucose not just by slowing absorption (fat effect) but by enhancing insulin action and possibly preserving beta-cell function. This is particularly relevant for those with metabolic dysfunction.