Avoid polyorbate-containing foods
The speaker details multiple studies: a 2018 study showed acute exposure to polyorbate 80 thinned the mucosal layer and increased E. coli translocation. Another study found that 0.1% polyorbate caused lysis across all cell models tested, and decreased transepithelial electrical resistance, indicating increased permeability. A 2021 microbiome study found lasting detrimental impacts on microbiota composition. Additionally, polyorbates increase LPS production from gram-negative bacteria, and the compromised barrier allows more LPS into the bloodstream, fueling inflammation. The speaker argues that the cumulative evidence is strong enough to warrant avoiding these emulsifiers entirely, as they are not essential and safer alternatives exist.
Polyorbates act as surfactants, thinning the mucosal layer and altering mucin gene expression. They cause cell lysis (cell death) at concentrations as low as 0.1%, decrease tight junction proteins (zonulin, occludin, claudin), and increase lipopolysaccharide (LPS) production and translocation. This leads to a 'leaky gut' and systemic inflammation.
The speaker shares that he now checks labels and avoids these ingredients, and he is 'digging hard on more research' for a future video.
The best thing you could do is just avoid this stuff.

