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Episode
This is Why You’re Not Building Muscle (6 Scientific Reasons)
~81 min
Episode Brief·YouTube

This is Why You’re Not Building Muscle (6 Scientific Reasons)

Thomas DeLauer
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TL;DR

The four things you'd lose by not watching

4 items

TL;DR

The four things you'd lose by not watching

4 items
1

Newbie gains are real but fleeting; after they plateau, you must increase training intensity or add stretch-mediated stimuli like static stretching to resume progress.

2

Protein intake, particularly leucine-rich and highly digestible sources (whey, milk, beef, eggs), is the single strongest predictor of hypertrophy—more than training variables.

3

To break through plateaus, add a few partial reps in the stretched position after reaching failure or near-failure, which significantly boosts muscle growth without extra volume.

4

As you age, muscle building slows due to higher leucine threshold, declining satellite cells, and elevated cortisol; practical fixes include pre-bed protein shakes, glycine, omega-3s, and carb timing at night.

Protocols

Concrete recipes — what, when, how much, and why

8 items

Static stretching for newbie gain amplification

WhatAdd 30 minutes of static stretching targeting large muscle groups (e.g., hamstrings) twice per week alongside a standard resistance training program.
WhenOn non-training days or after workouts, during the early phase of training (newbie phase) to capitalize on stretch-mediated hypertrophy.
Dose30 minutes per session, 2 times per week; stretch to the point of moderate discomfort (not pain).
For whomNovice lifters or those whose newbie gains have stalled and are still relatively new to structured training.
WhyStatic stretching in untrained individuals strongly activates stretch-mediated hypertrophy pathways, dramatically increasing strength and muscle growth beyond training alone.
CaveatsEffect is much smaller in experienced lifters; stretching must be intense enough to cause a real stretch sensation, not gentle flexibility work.

DeLauer highlights a study from the Journal of Strength and Conditioning where two groups followed identical resistance programs, but one group added 30 minutes of static stretching twice weekly. The stretching group saw a 31% increase in leg press strength vs 9% in the control, and similar outsized gains in leg extension and hamstring curls. The mechanism is stretch-mediated hypertrophy, where prolonged tension on muscle fibers triggers anabolic signaling. He stresses that this is 'low-hanging fruit' for anyone in the early stages of training who has hit a plateau, as it requires no extra joint stress or loading.

Mechanism

Prolonged static stretching applies mechanical tension to muscle fibers while they are elongated, activating stretch-sensitive anabolic pathways (likely involving titin and mechanosensitive ion channels) that enhance muscle protein synthesis and hyperplasia signals. In untrained muscles, this pathway is hyper-responsive, explaining the massive gains.

they had a 31% increase in their leg press strength compared to 12 just by adding stretching in. There's a 27% increase compared to a 14% increase in leg extension.

Also said
“now we don't see the same thing with static stretching when you are a more experienced lifter. You see a slight improvement, but when you're really in the newbie phase, you can get a lot more out of this.”— Clarifies that this protocol is phase-specific.

Stretch-position partial reps after failure

WhatAfter reaching failure or near-failure (1-2 reps in reserve) on a set, immediately perform 2-3 additional partial reps only in the stretched (lengthened) portion of the movement.
WhenAt the end of the final set(s) of an exercise, especially for isolation movements like biceps curls, leg extensions, or hamstring curls.
Dose2-3 partial reps, moving through the initial 15-30% of the range of motion where the muscle is most stretched.
For whomIntermediate to advanced lifters who have plateaued on a given exercise and want to increase growth stimulus without increasing overall volume.
WhyThe stretched position is most anabolic; adding partials there extends time under tension in that specific range without requiring complete reps, boosting hypertrophy with minimal added fatigue.
CaveatsEnsure the partials are in the lengthened position, not the contracted position; performing partials in the shortened range may not yield the same benefit.

DeLauer cites a European Journal of Sports Science study comparing full ROM, initial stretch partials, and terminal contraction partials. The stretch partials produced superior muscle cross-sectional area increases. He applies this by recommending that after you can no longer complete full reps, you add a few small partials in the beginning of the concentric—e.g., the bottom quarter of a bicep curl or the first part of a leg extension. This technique targets the muscle fibers in their lengthened state, which recent research shows is especially potent for hypertrophy, and serves as a 'plateau buster' that can unlock new growth without overloading the system.

Mechanism

The lengthened position engages stretch-mediated hypertrophy signals, likely via titin kinase activation and increased mechanotransduction, while also causing greater myofibrillar damage or stress in that range. By adding partials only there, you amplify the growth signal before fatigue prevents you from reaching that range in full reps.

Personal experience

It's worked tremendously well for me and it's a great plateau buster to kind of break through to a little bit more muscle growth.

when you finish your set and you go to failure or close to failure, if you can't go all the way to failure or even if you do go all the way to failure, pump out a few extra partial reps. ... It should ideally be in the stretched position though.

Also said
“they actually found that the stretch range of motion elicited significant strength and muscle growth.”— Directly supports the efficacy of focusing on the stretched partials.
“This is a great breakthrough way to get more muscle without really adding a lot more stress and volume to your workouts.”— Highlights the practical advantage of this technique.

Pre-bed protein shake for older adults

WhatConsume a protein shake made with water (no milk, no carbs) right before sleep.
WhenNightly, just before going to bed.
DoseOne serving of protein powder (~20-30g) mixed with water; not a meal replacement.
For whomPeople aged 40 and above who struggle to build muscle or maintain mass, especially those with insufficient total daily protein intake.
WhyOlder individuals have a higher leucine threshold to trigger muscle protein synthesis; a pre-sleep protein bolus provides the needed amino acids overnight without impairing sleep or fat oxidation.
CaveatsUse only protein powder and water; adding milk or carbs could affect digestion or sleep. Ensure total daily protein is adequate.

DeLauer explains that aging increases the leucine threshold required to activate mTOR and myofibrillar growth, yet many older adults inadvertently reduce protein intake. He references a conversation with researcher Dr. Mike Ormsby, who demonstrated that a pre-sleep protein shake did not disrupt sleep stages or reduce overnight fat burning, and in fact increased muscle protein synthesis and recovery. DeLauer frames this as a simple, purely supplemental strategy to bridge the gap and ensure the body has enough leucine overnight to support repair.

Mechanism

During sleep, the body undergoes repair and growth hormone release. Providing a slow-to-digest protein (like casein or a whey-casein blend) ensures a sustained elevation of amino acids and leucine in the bloodstream, crossing the age-related higher threshold and stimulating nocturnal muscle protein synthesis via mTORC1 activation.

One simple thing you can do is if you're in your 40s, just have a protein shake before bed. No carbs added to it. Just protein powder and water. Don't even do milk.

Also said
“He really opened my eyes showing that having a protein shake before bed did not disrupt sleep did not reduce fat burning in the morning.”— Adds expert validation that counters common fears.

Nightly glycine for cortisol reduction

WhatTake 3 grams of glycine in the evening.
WhenAt night, likely before bed.
Dose3 grams of glycine.
For whomIndividuals experiencing chronic stress or elevated cortisol levels, especially older adults.
WhyGlycine has calming properties that help lower cortisol, creating a more anabolic environment overnight.

Glycine can help calm you down a little bit. So I recommend like three grams of glycine, particularly at night.

Omega-3 intake for anabolism and inflammation

WhatConsume 2,000–3,000 mg of omega-3 fatty acids daily.
WhenDaily, ideally with meals.
Dose2,000–3,000 mg per day.
For whomOlder individuals or those with systemic inflammation hindering muscle growth.
WhyOmega-3s enhance muscle protein synthesis (via P70S6K phosphorylation) and provide anti-inflammatory effects, countering age-related catabolism.

Omega-3s not only have a powerful effect on muscle protein synthesis and what's called P7S6K phosphorilation ... but there's also an anti-inflammatory effect with omega-3s. So, I recommend like maybe 2 to 3,000 milligrams of omega-3s per day, especially if you're older.

Evening ashwagandha for cortisol balance

WhatTake ashwagandha in the evening to regulate cortisol.
WhenEvening time.
DoseUnspecified dose.
For whomThose with high evening cortisol or stress-driven catabolism.
WhyAshwagandha has an anti-cortisol effect, helping to balance the stress response and improve morning cortisol levels.

Ashwagandha in the evening time has an anti-cortisol effect. It can actually regulate cortisol so that when you get up in the morning, you're a little more balanced, too.

Evening carbohydrate allocation

WhatConsume most of your daily carbohydrates (50-60g) at night.
WhenEvening, with dinner or as a pre-bed snack.
Dose50–60 grams of carbs.
For whomIndividuals trying to build muscle while managing stress and sleep quality.
WhyCarbohydrates in the evening help blunt cortisol and improve sleep, supporting muscle building without necessarily increasing fat gain.
CaveatsAvoid junk food; the carbs should be from quality sources. Not for those on very low carb diets.

carbs aren't that important for building muscle. Protein is important for building muscle. ... if you allocate your carbs to the evening time, it'll help you sleep. It also blunts cortisol a little bit. ... like 50, 60, might be very beneficial.

Gut healing protocol for reducing systemic inflammation

WhatConsume bone broth, collagen protein, and gelatin to support the gut mucosal layer; avoid polyorbate emulsifiers; favor soy/sunflower lecithin; maintain clear gaps between meals (3-5 hours) for gut repair.
WhenDaily dietary practice; gap between meals consistently.
DoseOngoing lifestyle; bone broth/collagen as desired; meal gaps of at least 3-5 hours without snacking.
For whomIndividuals with signs of chronic inflammation, digestive issues, or unexplained plateaus in muscle growth.
WhyPoor gut barrier integrity leads to lipopolysaccharide leakage and systemic inflammation, which impairs muscle protein synthesis and promotes protein degradation.
CaveatsThis is a long-term strategy, not a quick fix. Inflammation is complex, and severe cases may need medical guidance.

DeLauer argues that inflammation often originates in the gut, as increased permeability allows bacterial lipopolysaccharides to enter the bloodstream, triggering an immune response that upregulates NF-kB and muscle protein degradation. Healing the gut mucosal layer with collagen, gelatin, and bone broth, while avoiding dietary emulsifiers (especially polysorbates), reduces that inflammatory load. He also emphasizes that the gut repairs itself during periods of non-eating, so having defined gaps between meals supports the migrating motor complex and gut barrier integrity.

Mechanism

The gut mucosal layer, composed largely of glycine-rich proteins, prevents translocation of lipopolysaccharides (endotoxins) from Gram-negative bacteria. When the barrier is compromised, LPS activates Toll-like receptor 4 on immune cells, leading to NF-kB activation, which drives inflammatory cytokines and directly suppresses muscle protein synthesis while promoting protein degradation via the ubiquitin-proteasome pathway. Collagen and gelatin provide the amino acids needed to rebuild the mucosal layer, and meal gaps allow for the clearance of bacteria and repair processes.

If we have more gut permeability we are having more lipopolyaccharides more inflammatory molecules that are secreted by gram negative bacteria in our messed up gut biome. They secrete out of the gut and into the bloodstream cause our immune system to turn on which creates ... an unfavorable environment not only for building muscle but also a favorable environment for storing fat.

Also said
“collagen is good for the joints, but really darn good for the gut.”— Emphasizes the dual benefit, redirecting collagen's reputation.
“The gut repairs itself when you're not eating. So you need to repair the gut if you want to get inflammatory systems under control.”— Justifies the meal spacing component.

What's new

Personal practice updates, fresh positions, predictions

5 items

Static stretching amplifies newbie gains

Adding 30 minutes of static stretching twice per week to a novice resistance training program can triple strength and hypertrophy gains compared to training alone.

Why this matters: Challenges the common belief that stretching before/after training provides minimal benefit; the magnitude of improvement (31% vs 9% leg press) is staggering and specific to novices.

Background

Typical newbie gains come easily with minimal training intensity. Once these stall, lifters often increase volume without knowing that stretching can unlock additional gains.

Thomas DeLauer describes a study where two groups of novice lifters followed the same resistance program, but one group added 30 minutes of static stretching twice a week. The stretching group saw a 31% increase in leg press strength, a 27% increase in leg extension, and superior hypertrophy compared to the non-stretching group's 9%, 14%, and 12% respectively. He emphasizes that this effect is most pronounced during the newbie phase, because stretch-mediated hypertrophy pathways are highly responsive when the muscles aren't conditioned to stretch. He frames this as 'low-hanging fruit' — a simple, non-stressful addition that can reboot progress after the initial easy gains end.

The group that added the stretching in, they had a 31% increase in their leg press strength compared to 12 just by adding stretching in.

Also said
“There's something called the stretch mediated hypertrophy response. And this could be really beneficial if you're trying to capitalize on your newbie gains.”— Introduces the mechanism term and reframes stretching as a hypertrophy tool, not just flexibility.
“If you are someone that's been training for a little while and your results have sort of stopped, this might be the next best thing for you to do.”— Directly links to the plateau problem, making it actionable.

Protein digestibility score (DIAAS) as the key metric

Beyond total protein and leucine content, the ileal digestibility (DIAAS score) determines how much of a protein actually gets absorbed; whey, milk, beef, and eggs top the list.

Why this matters: Shifts the conversation from grams per day to absorption efficiency, emphasizing that not all high-protein foods are equal for muscle building.

Background

Most fitness advice focuses on hitting a daily protein target (e.g., 1.6–2.2 g/kg) without considering digestibility. DeLauer argues that poor digestibility can make even high-leucine proteins ineffective.

DeLauer references a large meta-analysis showing that protein intake was the single largest predictor of hypertrophy. He then dives into two nuances: leucine content and the DIAAS (Digestible Indispensable Amino Acid Score). The DIAAS score measures actual ileal absorbability, i.e., how much of the ingested protein is absorbed in the small intestine. He instructs viewers to search for 'proteins with the highest DIAAS score' to find the most efficient muscle-building proteins. He lists whey protein, milk protein (whey + casein blend), beef, and eggs as the top performers. This approach gives a scientific method to choose protein sources, rather than relying solely on quantity.

There's a couple different scoring systems. There's the DASS score and the PDCAS score. You want to focus on the DIAS score. This is a protein digestibility score that has been truncated to ultimately figure out the best protein absorbability so you can really get the most out of it.

Also said
“Protein intake was the single largest predictor of if people built muscle or not.”— Underpins the urgency of getting protein right, making the digestibility nuance even more critical.

Partial reps in the stretched position as a plateau buster

After reaching failure on a set, performing 2-3 additional partial reps only in the stretched (lengthened) position significantly increases hypertrophy without adding full-range volume.

Why this matters: Provides a science-backed, low-fatigue method to increase muscle growth past plateaus, supported by recent research on range of motion and stretch-mediated hypertrophy.

Background

As lifters progress, increasing volume or weight becomes unsustainable. Partial reps are often dismissed as 'cheating', but here they are intentionally applied in the lengthened position to enhance growth.

DeLauer discusses research from the European Journal of Sports Science comparing full range of motion, initial partials (stretched), and terminal partials (contracted). The initial stretch range of motion elicited the greatest muscle cross-sectional area increases. He applies this by recommending that after a set taken to failure (or one rep in reserve), you pump out a few extra small partials in the stretched position — the bottom of a bicep curl or the beginning of a leg extension. This taps into the stretch-mediated hypertrophy pathway without significantly increasing systemic fatigue or session volume. He personally vouches for it as a 'tremendous' plateau breaker.

Personal experience

It's worked tremendously well for me and it's a great plateau buster to kind of break through to a little bit more muscle growth.

They actually found that the stretch range of motion elicited significant strength and muscle growth. ... when you finish your set and you go to failure or close to failure, ... pump out a few extra partial reps. This is really real stuff. It should ideally be in the stretched position though.

Also said
“What this means is that when you finish your set ... if you can't go all the way to failure or even if you do go all the way to failure, pump out a few extra partial reps.”— Clarifies the practical application, making it accessible.
“We're talking significant hypertrophy from doing this. This is a great breakthrough way to get more muscle without really adding a lot more stress and volume to your workouts.”— Emphasizes the efficiency benefit.

Pre-sleep protein shake for older lifters

Having a pure protein shake (no carbs) before bed can cross the elevated leucine threshold in older individuals, enhancing overnight muscle protein synthesis without impairing sleep or fat burning.

Why this matters: Directly counters the fear that eating before bed disrupts sleep or leads to fat gain; supported by a protein timing researcher's evidence.

Background

Aging raises the leucine threshold needed to trigger muscle protein synthesis, while appetite and protein intake often decline. Bedtime eating is commonly avoided for fear of fat storage.

DeLauer explains that as we age, we need more leucine to activate mTOR and build muscle, but older adults often consume less protein. He cites Dr. Mike Ormsby, a protein timing researcher he hosted on his channel, who demonstrated that a pre-sleep protein shake did not reduce sleep quality or fat oxidation, and instead improved recovery and muscle protein synthesis. DeLauer recommends a simple mix of protein powder and water (no milk, no carbs) before bed purely as a supplement—not a meal—to hit that heightened leucine threshold.

One simple thing you can do is if you're in your 40s, just have a protein shake before bed. No carbs added to it. Just protein powder and water. Don't even do milk. Just do prote. purely supplemental at this point and that's all you really need to get that extra protein to cross that threshold a lot of times.

Also said
“He really opened my eyes showing that having a protein shake before bed did not disrupt sleep did not reduce fat burning in the morning. As a matter of fact, it just increased recovery and increased muscle protein synthesis.”— Adds third-party research credibility to the recommendation.

Gut inflammation impedes muscle building

Systemic inflammation often originates in the gut; leaky gut releases lipopolysaccharides that trigger an immune response, blocking muscle protein synthesis and promoting protein degradation.

Why this matters: Shifts the focus from training variables to gut health as a fundamental bottleneck for muscle growth, linking dietary emulsifiers and gut barrier integrity to hypertrophy outcomes.

Background

Many lifters blame poor muscle gains on insufficient training or protein, ignoring chronic low-grade inflammation. DeLauer positions gut permeability as a hidden culprit.

DeLauer explains that as we age, cellular debris and oxidative stress activate NF-kB, driving muscle protein degradation. However, he argues that a primary source of systemic inflammation is the gut. Disruption of the gut barrier allows lipopolysaccharides from Gram-negative bacteria to enter the bloodstream, activating the immune system and creating a catabolic environment. To heal the gut, he recommends bone broth, collagen protein, and gelatin to support the mucosal layer, avoiding emulsifiers like polysorbate-60/80 (opting for soy or sunflower lecithin instead), and incorporating polyphenols as prebiotics. He also stresses the importance of clear gaps between meals to allow gut repair through the migrating motor complex.

Inflammation really does, in my opinion, for most people, start in the gut. ... we have more gut permeability we are having more lipopolyaccharides more inflammatory molecules that are secreted by gram negative bacteria in our messed up gut biome.

Also said
“At the cellular level you have inflammation, you have protein degradation and you have oxidative stress ultimately turning on this like nuclear factor kappa B which is at a very genetic level just triggers this muscle protein degradation.”— Connects gut-derived inflammation directly to muscle protein breakdown at the genetic level.

Recommendations

Products, supplements, and tools mentioned in the episode

7 items

Glycine

Supplement

Taking 3 grams of glycine at night is recommended for lowering cortisol and improving sleep, which supports an anabolic environment.

I recommend like three grams of glycine, particularly at night.

Find Glycine

Omega-3 fatty acids

Supplement

Daily dose of 2,000–3,000 mg recommended for its anabolic effects on muscle protein synthesis and anti-inflammatory benefits.

I recommend like maybe 2 to 3,000 milligrams of omega-3s per day, especially if you're older.

Find Omega-3

Ashwagandha

Supplement

Taken in the evening to help regulate cortisol and promote a more balanced hormonal state.

Ashwagandha in the evening time has an anti-cortisol effect.

Find Ashwagandha

Tonat Ali (Tongkat Ali)

Supplement

Recommended as a natural way to support testosterone levels, which decline with age and impact muscle building.

Personal experience

Tonat Ali ... really made a big difference for me.

I do recommend things like Tonat Ali is really, really good for that. It's like really made a big difference for me.

Find Tonat

DIM (Diindolylmethane) / Cruciferous vegetables

Supplement

Helps modulate estrogen levels; women may need to manage estrogen decline, while men can benefit from balancing estrogen relative to testosterone.

I recommend things like dim dandolmethane or just consuming more in the way of cruciferous vegetables. So cabbage, broccoli, cauliflower.

Find DIM

Vitamin C

Supplement

Mentioned as helpful for cortisol reduction, likely as part of a stress management supplement stack.

Vitamin C is very good for cortisol reduction.

Find Vitamin

Consuming bone broth and collagen for gut health

Practice

Bone broth and collagen protein help heal the gut mucosal layer, reducing systemic inflammation that blocks muscle growth.

things like bone broth, things like collagen protein to help heal the gut. Sure, collagen is good for the joints, but really darn good for the gut.

Find Consuming
Disclosed sponsorships1speaker disclosed

Bomar Nutrition Whey Protein

Product Sponsored · disclosed

Recommended as a high-quality, great-tasting whey protein that is sweetened with allulose (not sucralose) and provides a large amount of protein per serving.

DisclosureThomas DeLauer has an affiliate link in the video description offering a 15% discount.

DeLauer praises Bomar Nutrition's whey as the best-tasting protein he's ever had, comparing it to a McDonald's milkshake (specifically the strawberry milkshake flavor). He highlights that it uses allulose as a sweetener rather than sucralose, making it a cleaner option. The protein is positioned as a top choice to meet protein needs, especially for those who struggle with palatability or artificial ingredients.

vs alternatives

Compared implicitly to other protein powders that use artificial sweeteners like sucralose, and to the taste of traditional protein shakes which are often gritty or artificial.

Personal experience

This is my go-to when it comes down to whey protein. the best tasting protein I have ever had in my life. It does not even taste like protein powder. It legit tastes like a McDonald's milkshake.

their strawberry milkshake flavor is usually my go-to because if I was to go to McDonald's, I would get a strawberry milkshake. This stuff, I tell you, you do not feel like you are having a protein shake.

Find Bomar

Notable quotes

Lines worth pulling out — contrarian, specific, or perfectly phrased

6 items
protein intake was the single largest predictor of if people built muscle or not.
Emphasizes the primacy of protein over any training variable, a bold and actionable statement supported by a large meta-analysis.
the group that added the stretching in, they had a 31% increase in their leg press strength compared to 12 just by adding stretching in.
The specific magnitude of effect (nearly 3x) makes a compelling case for static stretching as a newbie strategy.
cortisol... elicit atrophy by triggering protein degradation. It actually, it sounds weird, but it triggers more autophagy because your body's going through more autophagy to try to recycle and salvage what it has already. And this autophagy can sometimes break down protein.
Clarifies the nuanced role of autophagy—often seen as beneficial—in the context of chronic stress, which can actually degrade muscle.
Inflammation really does, in my opinion, for most people, start in the gut.
A strong and somewhat contrarian statement that positions gut health as the root of systemic inflammation and muscle-building plateaus.
carbs aren't that important for building muscle. Protein is important for building muscle. Stimulus is important for building muscle.
Direct and unambiguous prioritization of protein and training over carbohydrate intake for hypertrophy, challenging common bulking advice.
What this means is that when you finish your set and you go to failure or close to failure, if you can't go all the way to failure or even if you do go all the way to failure, pump out a few extra partial reps. This is really real stuff.
Captures the practical essence of the partial rep technique with conviction, making it sound like a secret weapon.

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Topics covered

newbie-gainsprogressive-overloadstretch-mediated-hypertrophystatic-stretching-for-muscleprotein-intakeleucine-thresholdprotein-digestibilitydiaas-scorewhey-proteintraining-to-failurereps-in-reservemuscle-fiber-typepartial-repsstretch-position-trainingage-related-muscle-losssatellite-cellsmtor-attenuationleucine-and-agingprotein-before-bedtestosterone-decline
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Educational summary of the cited expert source — not medical advice. Open the source recording linked above and consult a qualified physician before acting on any protocol.