Match number of exercises to weekly frequency
Israetel frames exercise number purely as a tool to accommodate total sets. If a muscle is hit three times a week, you need fewer sets per session, so one exercise can usually provide 5-7 hard sets. If that's insufficient, you can stay at 1 exercise and add a set, or add a second exercise. On a once-a-week split, you may need 10-15 sets, which would be stale on a single movement, so 2-3 exercises become necessary to manage staleness and junk volume. He emphasizes that the question of how many exercises must always be answered by first asking, 'How many sessions per week do you do for that muscle?' This frequency-first logic is the core of his system.
Israetel illustrates with a hypothetical: 'If I do biceps Monday, Wednesday, Friday, then I do one kind of bicep curl on Monday, one kind on Wednesday, and one kind on Friday.' While not a personal anecdote, it shows how he'd apply the principle.
If you are doing three sessions or more per week, my recommendation is starting just with one exercise per session. … If you train a muscle one to two times per week … three exercises per session are absolutely an option.

