High-dose creatine + sodium for brain uptake
DeLauer explains that many people take 5 g of creatine thinking it benefits the brain, but the brain is essentially last in line. The muscle and liver saturate first, leaving what he calls 'sloppy seconds' for the brain. He points out that creatine does not easily cross the blood-brain barrier—it is restricted. So to get a meaningful amount into the CNS, you either take huge doses (which he dislikes due to water retention) or you enhance transport. The key is sodium. He references a previous study showing a 47% increase in brain creatine uptake when sodium, magnesium, and calcium are optimized. He therefore recommends adding 500 mg of sodium alongside the creatine, and ensuring that magnesium and calcium are adequate. He says this is a temporary protocol for a 30-day sprint.
Creatine is transported into the brain via the sodium-chloride-dependent transporter SLC6A8. A sodium gradient is required for this process, and adequate intracellular magnesium and calcium support the gradient. Without enough sodium, creatine cannot effectively cross the BBB, and the brain receives only a fraction of supplemental creatine. High doses (15–20 g) are needed because tissue saturation prioritizes muscle and liver.
He says, 'I don't personally like taking 20 or 30 g of creatine. That's a whole lot because I start to retain some water. So, there's a couple things that you can do. For one, like 15 to 20 grams is probably a good place to be if you needed to do it temporarily to increase that brain function.'
Creatine in order to cross the blood brain barrier actually needs a sodium gradient. So it actually needs a little bit of sodium to properly get across the blood brain barrier.

