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1/2 Cup Lowers Insulin, Shrinks Belly Fat and Repairs Mitochondria (works fast)
~44 min
Episode Brief·YouTube

1/2 Cup Lowers Insulin, Shrinks Belly Fat and Repairs Mitochondria (works fast)

Thomas DeLauer
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TL;DR

The four things you'd lose by not watching

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TL;DR

The four things you'd lose by not watching

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Protocols

Concrete recipes — what, when, how much, and why

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Avoid antiseptic mouthwash to protect oral nitrate-reducing bacteria

WhatStop using antiseptic mouthwash; brush and floss normally without antibacterial agents.
WhenEveryday oral hygiene routine.
DoseContinuous avoidance (permanent practice).
For whomAnyone using mouthwash, especially those concerned about nitric oxide, circulation, or metabolic health.
WhyAntibacterial mouthwash kills the commensal bacteria on the tongue that convert dietary nitrate to nitrite, shutting down the backdoor nitric oxide pathway.
CaveatsNone mentioned; just avoid harsh antibacterial mouthwashes.

So if you're using like an antiseptic mouthwash, you're literally wiping out the very bacteria that make the system work in the first place. So you want to skip the harsh mouthwash, okay? It's flat out sabotaging nitric oxide production.

Daily mini arugula + beet salad for a backdoor nitric oxide reset

WhatEat a small salad of arugula and beets at lunch.
WhenLunch (midday meal).
DoseA handful of arugula with some sliced beets, once daily.
For whomGeneral population wanting to boost nitric oxide, energy, and vascular health without powders or supplements.
WhyProvides high levels of dietary nitrates that are converted to nitric oxide via the oral microbiome, bypassing impaired NOS enzyme systems.
CaveatsSpinach is an alternative but is high in oxalates; arugula is preferred.

Then add like a small mini arugula salad with some beets at lunch. That's like a nice little backdoor nitric oxide reset.

Nitrate pre-loading 60–90 minutes before mental or physical effort

WhatConsume a nitrate-rich food or beetroot powder 60–90 minutes before a workout or cognitively demanding task.
When60–90 minutes before the target activity.
DoseA serving that delivers substantial nitrate (e.g., arugula salad with beets, a shot of beet juice, or a scoop of beetroot powder).
For whomAthletes, students, or anyone seeking improved stamina and mental endurance.
WhyNitric oxide peaks roughly 60–90 minutes after ingestion, improving mitochondrial efficiency and oxygen utilization exactly when energy demand is highest.
CaveatsIf fasting, use a low-calorie beetroot powder to avoid breaking the fast.

This protocol leverages the mitochondrial efficiency boost from dietary nitrates. By aligning peak nitric oxide with high-energy demand, you maximize the cellular effects. Thomas suggests it’s not just for physical workouts but also for mental tasks, as the brain benefits from improved mitochondrial function. He offers a Mediterranean-inspired recipe: an arugula base with roasted beets, olive oil, and sea salt, or a blended arugula–beet powder drink for a portable, low-carb option.

Mechanism

Nitrate-derived nitric oxide improves mitochondrial coupling by reducing ATP/ADP translocase-mediated energy leaks, leading to more ATP per oxygen. Consuming nitrate 60–90 minutes before activity ensures peak NO availability coincides with the period of greatest mitochondrial oxygen demand, amplifying the efficiency effect.

You can consume a nitrate rich food or be powder or peak juice like anything like that 60 to 90 minutes before your workout, but more importantly before like a mentally demanding task. Okay? That's when nitric oxide would peak.

Also said
“So you're stacking your body's highest demand with arguably your highest efficiency.”— Succinctly captures the logical basis of the timing strategy.
“You could probably literally feel your energy stabilize and like your mental endurance last longer.”— Adds a subjective expected outcome that motivates experimentation.

Pair nitrate vegetables with your largest carb meal to blunt blood sugar spikes

WhatInclude nitrate-rich vegetables (arugula, beets, celery) with your highest carbohydrate meal of the day.
WhenWith the meal containing the most carbs (often dinner).
DoseA generous portion (e.g., arugula as a salad base with pasta, roasted beets alongside sweet potatoes).
For whomPeople with insulin resistance, pre-diabetes, or anyone wanting stable glucose levels and sustained energy.
WhyNitrate upregulates GLUT4 transporters, enabling muscles to pull glucose from the blood more efficiently, thereby reducing the post-meal glucose spike and lowering insulin demand.
CaveatsEnsure the nitrate source doesn’t unnecessarily add carbs if following a strict low-carb diet—arugula is extremely low in carbs and fits well.

Thomas explains that by combining nitrate vegetables with a carb-rich meal, you essentially ‘pre-install’ more GLUT4 doors on muscle cells before the glucose surge arrives. This allows glucose to be taken up more rapidly without waiting for a massive insulin pulse. Practical examples include topping pasta or rice bowls with arugula, or roasting beets with sweet potatoes. He claims the effect begins within hours, flattening the blood sugar curve and sparing the pancreas.

Mechanism

Nitrate-derived nitric oxide increases the expression of GLUT4 transporters on muscle and fat cells. Post-meal, these additional transporters facilitate insulin-independent glucose uptake, blunting the amplitude and duration of blood glucose elevation and reducing the compensatory insulin response.

So, as glucose is entering the bloodstream, you're flattening that blood sugar spike and that rise and you're keeping your energy more stable and taking the stress off of the pancreas.

Also said
“If you were to just add maybe some arugula to your carb meal tonight, you're already improving your glucose control quite literally within a few hours.”— Highlights the immediate, same-day benefit, making the protocol compelling.
“You could add like arugula to your pasta, which actually tastes really good.”— Offers a simple culinary example that lowers the barrier to adoption.

Nitrate amplification with intermittent fasting, hormetic stress, and oral care

WhatCombine regular nitrate intake with intermittent fasting, cold or heat exposure, and the avoidance of antiseptic mouthwash to synergistically boost mitochondrial and nitric oxide pathways.
WhenIncorporate into daily/weekly routine: fasted window (e.g., 16:8), nitrate with meals, cold/heat exposure a few times per week.
DoseStandard intermittent fasting schedule; nitrate as per previous protocols; cold or heat exposure according to personal tolerance (e.g., a few minutes of cold shower or a sauna session 2–3 times per week).
For whomThose already exploring fasting or hormetic therapies who want to maximize metabolic efficiency and resilience.
WhyIntermittent fasting activates SIRT1, extending nitric oxide’s mitochondrial benefits; cold/heat exposure drives mitochondrial biogenesis; preserving the oral microbiome ensures dietary nitrates are converted to nitric oxide—all pathways converge on the same mitochondrial health axis.
CaveatsNot appropriate for everyone (pregnancy, certain medical conditions); start gradually with cold exposure and consult a physician if unsure.

Thomas paints a convergence model: dietary nitrates, intermittent fasting, and hormetic stressors all feed into overlapping mitochondrial and NO pathways. Fasting via SIRT1 activation amplifies the mitochondrial efficiency gains from nitrates. Cold/heat exposure triggers mitochondrial biogenesis through uncoupling signaling, increasing the total cellular engine count. And preserving the oral microbiome keeps the nitrate-to-nitrite conversion operational. He stresses that removing antiseptic mouthwash is a simple but often overlooked step, as many people unknowingly sabotage their own NO production nightly.

Mechanism

SIRT1 deacetylates PGC-1α, promoting mitochondrial biogenesis and efficiency, complementing nitrate’s leak-plugging effect on ATP/ADP translocase. Cold and heat stress mildly uncouple mitochondria, acting as a signal to increase mitochondrial density over time. Oral bacteria reduce nitrate to nitrite, initiating NO synthesis; mouthwash kills these essential microbes, blocking the entire dietary nitrate pathway.

combine it with intermittent fasting, right? So, this is going to extend nitric oxide to mitochondrial benefits through what's called cert one activation. And then also cold or heat exposure. This triggers what's called mitochondrial biogenesis through uncoupling signaling.

Also said
“So all of these things converge like a little bit of fasting, a little bit of hormatic stressors, taking care of the oral biome and they all converge in the same nitric oxide mitochondrial pathways.”— Emphasizes the synergistic overlap that makes the combination more powerful than any single intervention.
“You don't want to destroy the bacteria that start this whole process in the first place.”— A simple, forceful reminder about oral microbiome hygiene as the foundation of the nitrate pathway.

7-day tier‑1 nitrate food challenge

WhatPick one tier‑1 nitrate food (arugula recommended) and add it once a day for seven consecutive days to observe how it affects energy and well‑being.
WhenOnce daily; timing can follow the performance or glucose protocols.
DoseOne serving per day for 7 days.
For whomBeginners who want a simple, testable entry point into dietary nitrate protocols.
WhyConsistent intake allows the mitochondrial and insulin‑sensitizing effects to build up; arugula provides the highest nitrates with minimal oxalates.
CaveatsSpinach is an alternative but is high in oxalates; stick to arugula or beet products if oxalates are a concern.

pick like a power food from tier one and commit to adding it like once a day for 7 days straight. Just see how you feel with that.

What's new

Personal practice updates, fresh positions, predictions

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nitrate-nitrite-nitric-oxide-backdoor-pathway

early

When the body's primary nitric oxide synthase (NOS) system is impaired by stress, aging, or inflammation, dietary nitrates from vegetables are converted by tongue bacteria into nitrite and then to nitric oxide, bypassing the broken NOS pathway entirely.

Why this matters: This reveals a practical, food-based workaround to restore nitric oxide production that declines with age and stress, linking oral microbiome health directly to vascular and metabolic function—and shows that mouthwash can sabotage it.

Background

The NOS enzyme system is fragile and gets downregulated by common factors like chronic stress, inflammation, and aging, leading to low nitric oxide and consequently poor circulation, energy metabolism, and insulin sensitivity.

Thomas explains that the standard nitric oxide production relies on nitric oxide synthase (NOS) enzymes, which are easily compromised. He introduces a 'backdoor' pathway: dietary nitrate-rich vegetables (arugula, beets, etc.) are acted upon by commensal bacteria on the tongue, converting nitrate to nitrite. This nitrite is then further reduced to nitric oxide in the body, circumventing the impaired NOS system entirely. He emphasizes that this pathway is sabotaged if people use antiseptic mouthwash, which kills the necessary oral bacteria. He contrasts arugula as a top source with spinach, which is high in oxalates and should be used cautiously. The immediate takeaway is to drop mouthwash and add a mini arugula salad with beets at lunch to restart nitric oxide production.

The fix for this is the nitrate to nitrite nitric oxide pathway. This is the biological sort of back door if you want to call it that. So when you eat nitrate rich vegetables, your oral microbiome, which is the bacteria that's on your tongue, converts that dietary nitrate into something called nitrite. And then your body takes it the rest of the way and it turns it into what's called nitric oxide. And this completely bypasses the broken NOS system.

Also said
“So if you're using like an antiseptic mouthwash, you're literally wiping out the very bacteria that make the system work in the first place. So you want to skip the harsh mouthwash, okay? It's flat out sabotaging nitric oxide production.”— Adds the practical danger of mouthwash and underscores the oral microbiome's role.
“Arugula is the king. Spinach is good, but the oxalates, I mean, here are good now and then, I guess. Okay, beetroot and then also beet greens, so don't just throw out the leaves.”— Prioritizes the most effective nitrate sources while noting a caveat about oxalates.

mitochondrial-efficiency-via-nitrate-and-atp-adp-translocase

middle

Dietary nitrate (specifically from beets) lowers the protein ATP/ADP translocase, which otherwise leaks energy in mitochondria, resulting in more ATP produced with less oxygen—a direct enhancement of cellular energy efficiency.

Why this matters: Identifies a specific molecular target (ATP/ADP translocase) by which a common food improves mitochondrial coupling, turning dietary nitrate into a performance and cognitive enhancer.

Background

Mitochondria normally make ATP through oxidative phosphorylation, but inefficiencies—like protein-mediated proton or energy leaks—cause some energy to be wasted as heat, reducing the ATP yield per oxygen consumed.

Thomas cites a Cell Metabolism study showing that dietary nitrate from beets made mitochondria 'radically more efficient.' The compound reduced the activity of ATP/ADP translocase, a protein that can dissipate energy. By plugging this leak, mitochondria produced more ATP while consuming less oxygen. He translates this into a performance strategy: consuming nitrate 60–90 minutes before physical or mental work, so peak nitric oxide coincides with peak demand. He suggests a practical Mediterranean-style meal—arugula with roasted beets, olive oil, and sea salt—or blending arugula with beet powder for a low-carb pre‑workout.

There was a study that was published in cell metabolism that found that dietary nitrate, specifically from beets, made mitochondria radically more efficient. they ended up producing more ATP while consuming less oxygen. Mechanistically this happens because nitrate lowered a specific protein and this protein is called ATP ADP transllocase. So this protein would leak energy. Okay, this bad protein would leak energy and when that leak gets plugged your mitochondria stop wasting oxygen.

Also said
“It means that nitrates literally fine-tune your cellular engines. They make them run smoother. They make them run cleaner and more efficiently.”— Simplifies the biological mechanism into an intuitive metaphor for the listener.
“You can consume a nitrate rich food or be powder or peak juice like anything like that 60 to 90 minutes before your workout, but more importantly before like a mentally demanding task. Okay? That's when nitric oxide would peak.”— Provides the actionable timing window based on the pharmacokinetics of nitrate conversion.

insulin-mimetic-nitrate-upregulates-glut4-transporters

later

Nitrate supplementation increases GLUT4 glucose transporter levels by 215% in muscle and 344% in adipose tissue, effectively building more cellular doorways for sugar without requiring extra insulin—positioning nitrates as an insulin mimetic.

Why this matters: Presents a non-pharmacological dietary strategy to combat insulin resistance by upregulating GLUT4 expression independently of insulin, with direct study numbers that surpass typical supplement claims.

Background

Insulin resistance often involves a reduction in GLUT4 transporters or impaired translocation to the cell surface, forcing the pancreas to pump more insulin to clear glucose.

Thomas reframes nitric oxide beyond vasodilation, emphasizing that it opens 'cellular doorways' (GLUT4 transporters) for glucose. He references a study from the journal Nitric Oxide where nitrate supplementation raised GLUT4 levels by 215% in muscle and 344% in adipose tissue, meaning cells built more doors for sugar to enter without the need for extra insulin. The result was better glucose tolerance, lower fasting insulin, and less inflammation. His practical advice: pair nitrate-rich vegetables with the largest carb meal of the day—arugula on pasta, roasted beets with sweet potatoes—to flatten the post-meal blood sugar spike and reduce pancreatic stress. He claims the effect can begin within hours.

There was a study that was published in the journal nitric oxide and it found that nitrate supplementation increased glute 4 levels by 215% in the muscle and 344% in atapost tissue. So that means that your cells are virtually building more doors for sugar to enter without needing extra insulin.

Also said
“So, in human terms, it basically means that nitrates act like an insulin magnetic. They help your body control blood sugar better, and they do this without taxing your pancreas and asking it to produce more insulin.”— Captures the insulin-mimetic concept in accessible language.
“You could actually pair nitrates with your carbs. So, eat nitrate rich vegetables like celery or beets or whatever and eat it with your highest carb meal of the day. So, you could add like arugula to your pasta, which actually tastes really good.”— Shows the direct application of the science to real meals.

Recommendations

Products, supplements, and tools mentioned in the episode

1 item

Thomas DeLauer’s video on TMG (trimethylglycine)

Tool

He briefly mentions a dedicated video he made explaining TMG, a compound found in beets, and recommends watching it to learn more.

Now, I put a video here that explained TMG, trimethlycine, in its full scope. TMG is a compound that's in beats that I think you'll get a lot out of. So, I recommend you watch this video to learn a little bit more about it.

Find Thomas
Disclosed sponsorships1speaker disclosed

Element Electrolytes (LMNT)

Supplement Sponsored · disclosed

Thomas recommends this sugar‑free electrolyte powder to support mineral balance, blood flow, and nerve signaling. He uses it when fasting or cutting calories to curb appetite and boost energy.

DisclosureThomas provides a special link (drinklnt.com/thomas) that gives a free sample variety pack with any purchase.

He promotes Element as a zero‑sugar electrolyte mix with 1,000 mg sodium, 200 mg potassium, and 60 mg magnesium per serving. He personally drinks it during intermittent fasting and calorie‑restricted periods to manage hunger and maintain energy. He emphasizes that minerals are critical, often overlooked regulators of energy production and brain‑body communication.

Personal experience

I drink it when I'm fasting. I drink it when I'm cutting calories cuz it curbs my appetite. But also, I get an energy boost from it because we forget that minerals are a huge, if not one of the most important regulators of energy and how our brain actually sends signals to our body.

A good electrolyte is something that I always recommend and I put a link down below for a special link that gets you a free sample variety pack of element electrolytes with any purchase.

Also said
“1,000 millig sodium, 200 potassium, 60 magnesium. I drink it when I'm fasting.”— Lists the exact electrolyte doses and the personal use case.
Find Element

Notable quotes

Lines worth pulling out — contrarian, specific, or perfectly phrased

6 items
The fix for this is the nitrate to nitrite nitric oxide pathway. This is the biological sort of back door if you want to call it that.
Cleanly introduces the core concept of a dietary workaround for a broken primary NO system.
So if you're using like an antiseptic mouthwash, you're literally wiping out the very bacteria that make the system work in the first place. flat out sabotaging nitric oxide production.
Forceful, surprising warning that a common hygiene product directly undermines the health benefit described.
nitric oxide doesn't just open blood vessels. That's kind of old school, okay? It actually opens cellular doorways, specifically what's called the glute 4 transporter.
Dismisses the conventional ‘vasodilation only’ view of NO and pivots to a metabolic action on glucose entry.
nitrate supplementation increased glute 4 levels by 215% in the muscle and 344% in atapost tissue.
Delivers a highly specific, impressive percentage increase from a published study, making the claim concrete.
Arugula is the king. Spinach is good, but the oxalates, I mean, here are good now and then, I guess.
A blunt, colloquial ranking that cuts through nuance and gives the listener a clear top pick.
If you were to just add maybe some arugula to your carb meal tonight, you're already improving your glucose control quite literally within a few hours.
Promises an almost instant metabolic improvement from a tiny dietary tweak, making the advice feel immediately actionable.

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Topics covered

nitric-oxidedietary-nitratesoral-microbiomemouthwash-dangersmitochondrial-efficiencyatp-adp-translocaseglut4-transportersinsulin-resistancebeetrootarugulaelectrolyteselement-lmnttmgintermittent-fastingcold-exposureheat-exposure
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Educational summary of the cited expert source — not medical advice. Open the source recording linked above and consult a qualified physician before acting on any protocol.