Cultivate at least 3 uplifting relationships and volunteer regularly
Berg frames loneliness as a chronic stressor that keeps cortisol high and creates a pro-inflammatory state. This state damages blood vessels, raises blood pressure, and increases susceptibility to heart disease and stroke. Beyond the cardiovascular system, he says that loneliness can suppress genes that regulate immunity, making people more vulnerable to cancer and infections. The antidote is not medication but deliberate social architecture: quality relationships — not just acquaintances — that provide genuine uplift, and volunteering, which he describes as therapeutic because helping another person diminishes one’s own stress burden. He suggests at least three regular, positive social contacts, though the exact frequency is left flexible.
Social connection reduces stress hormone output and likely reactivates immune-related genes that loneliness silences, lowering systemic inflammation.
quality relationships at least three that will lift you up is super therapeutic where you have a regular social engagement. Another thing to do is volunteer and help some group or some person because it's very therapeutic to help another.

