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Episode
They Found the Best Way to Detox Microplastics – And It’s Shockingly Simple
~38 min
Episode Brief·YouTube

They Found the Best Way to Detox Microplastics – And It’s Shockingly Simple

Thomas DeLauer
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TL;DR

The four things you'd lose by not watching

4 items

TL;DR

The four things you'd lose by not watching

4 items
1

Microplastics are excreted through stool, so the most promising detox strategy is to strengthen gut barrier integrity using 3–5g glutamine every other day, collagen, and bone broth; also avoid emulsifiers like polyorbates that break the gut mucosal layer.

2

Bile acid sequestration with soluble fiber (chia seeds, flax seeds) helps bind and flush fat-soluble micro/nanoplastics via stool, especially when combined with adequate hydration to improve transit time.

3

Polyphenols from fruit and extracts act as prebiotics and postbiotics, lowering gut inflammation and boosting endogenous antioxidant enzymes to mitigate inflammatory damage from microplastics.

4

Sponsor Timeline Nutrition’s urolithin A (Mitopure) supports mitochondrial health via mitophagy; the berry powder is a convenient form recommended by the expert.

Protocols

Concrete recipes — what, when, how much, and why

6 items

Gut Barrier Integrity Trio

WhatConsume collagen, bone broth, and 3–5g glutamine every other day to strengthen tight junctions in the intestinal lining.
WhenDaily for collagen/bone broth; glutamine every other day.
Dose3–5 grams glutamine, every other day; collagen and bone broth as part of regular diet (no specific doses given).
For whomGeneral adult audience, particularly those concerned about microplastic accumulation; individuals with gut issues may benefit most.
WhyA tighter gut barrier reduces the absorption of micro‑ and nanoplastic particles into the bloodstream, leading to more excretion via stool.
CaveatsDeLauer notes some people have concerns about glutamine; he does not address specific contraindications. Airborne and dermal absorption still occur.

DeLauer positions the gut as the primary gateway for microplastic entry, citing studies that smaller particles absorb easier. He acknowledges that stool can contain microplastics, so if fewer enter the bloodstream, more may end up in stool. The glutamine dose (every other day) is his empirical suggestion; he doesn't provide a study to back it but frames it as a practical measure. He also emphasizes that gut inflammation, often caused by emulsifiers like polyorbates, can further compromise the barrier, so this protocol is part of a larger gut‑centric strategy.

Mechanism

The intestinal epithelium relies on tight junction proteins to regulate paracellular permeability. Glutamine is a primary fuel for enterocytes, supporting cell turnover and junction protein expression. Collagen provides amino acids like glycine and proline that are used to repair the gut lining. Bone broth supplies glycosaminoglycans and additional collagen. Together they promote the integrity of the mucosal barrier, physically limiting the passage of small particles like microplastics.

We want to consume things like collagen. We want to consume things like bone broth. We want to consume 3 to five grams of glutamine probably every other day.

Also said
“what that means is that less, not all, but less microlastic and nanoplastic particles can get through and you're going to see potentially more end up in the stool.”— Directly connects the gut barrier protocol to microplastic excretion.

Avoid Polyorbate Emulsifiers

WhatEliminate foods and products containing polyorbate (e.g., polysorbate 60/80) from your diet.
WhenWhenever possible; read labels and avoid any item with polyorbate on the ingredients list.
DoseAvoid entirely.
For whomEveryone, especially those with gut sensitivity or a history of inflammatory conditions.
WhyPolyorbates damage the gut mucosal layer, break down tight junctions, and induce inflammation, which could increase microplastic absorption and systemic inflammation.
CaveatsPolyorbates are ubiquitous in processed foods; complete avoidance may be difficult. DeLauer argues the downstream harm is so great that limit exposure as much as possible.

DeLauer singles out polyorbates as a major avoidable trigger of gut inflammation. He says that inflammation starting in the gut can cascade into systemic issues: inflammatory responses leading to immune activation and chronic low‑grade inflammation. While not the only emulsifier, polyorbates are particularly egregious because of their documented effect on mucosal barriers. He argues that just by removing them, one can significantly reduce one source of gut damage, indirectly helping microplastic clearance by preserving barrier function.

Mechanism

Polyorbates are surfactants that can strip the protective mucus layer and disrupt epithelial tight junctions. In research, they are used to experimentally induce intestinal inflammation and lipopolysaccharide (LPS) translocation, leading to systemic inflammatory responses. A compromised gut barrier then becomes more permeable to larger particles like microplastics, creating a vicious cycle of inflammation and increased absorption.

polyorbate I'm just going to get on a limb and say it should probably never come in your body. Seeing how we use it in research settings to literally induce inflammation and lipopolyaccharides.

Also said
“when you think about the downstream effects of damaging your gut and breaking down that gut mucosal layer, that is my friends literally how inflammation can start in the body.”— Explains the broad health impact beyond microplastics.

Bile Acid Sequestration with Soluble Fiber

WhatConsume soluble fiber sources like chia seeds, flax seeds, or other soluble‑fiber‑rich foods to bind bile acids and sequester microplastics for stool elimination.
WhenDaily, with meals and adequate water intake.
DoseNo specific gram dose given; include a serving of soluble‑fiber food (e.g., 1–2 tbsp chia/seeds) regularly.
For whomAnyone looking to enhance microplastic excretion; also beneficial for cholesterol management and gut motility.
WhyBile acids can bind to fat‑soluble microplastics, and soluble fiber binds to bile acids, pulling them—and the attached particles—out of the digestive tract.
CaveatsMust be combined with sufficient water to avoid constipation. Evidence is early and indirect for microplastics specifically.

DeLauer presents this as the most promising specific intervention backed by early research on stool microplastics. He notes that bile acids naturally handle fat‑soluble toxins, and he extrapolates that nanoplastics, being capable of crossing membranes, could also be sequestered. The protocol is simple: any soluble fiber source (chia, flax, oats, etc.) plus water. He does not advocate for isolated bile acid sequestrants because food‑based fiber also feeds the microbiome and adds polyphenols.

Mechanism

The liver synthesizes bile acids to emulsify dietary fats. Soluble fiber forms a gel in the intestine that traps bile acids, preventing their reabsorption and promoting their excretion. Because many microplastics are lipophilic (fat‑loving), they may associate with lipid phases in the gut, and bile acids can sequester these lipophilic compounds. The fiber‑bile acid complex then carries the bound material out via feces. Hydration ensures that stool remains soft and transit time short, reducing re‑absorption opportunity.

bile acid sequestration is where bile acids actually sequester some of the fat soluble things and even toxins in our gut and help move them out. So what you do is you use things like soluble fiber, chia seeds, flax seeds, anything with good amounts of soluble fiber

Also said
“the bile acids are going to potentially bind to the nanoplastics, the microplastics and move it through the stool better along with proper hydration”— Shows the direct link to microplastic elimination.
“how do we improve transit time? Drink more water.”— The companion step that makes the sequestration effective.

Polyphenol-Rich Diet for Gut Health and Anti-inflammation

WhatIncorporate polyphenol‑rich foods such as fruits, fruit extracts, or concentrated juices to promote a healthy gut microbiome and reduce inflammation.
WhenDaily, as part of a balanced diet; optionally use extracts.
DoseNo specific dose; emphasize bright‑colored fruits and possibly polyphenol extracts.
For whomEveryone, especially those avoiding high‑fiber roughage due to IBS or gut sensitivity.
WhyPolyphenols act as prebiotics and postbiotics, improving microbial composition and gut barrier function, while also inducing endogenous antioxidants like superoxide dismutase and glutathione peroxidase, which may counteract microplastic‑induced inflammation.
CaveatsHe cautions that some people with IBS may find high‑fiber roughage problematic; polyphenols from fruits or extracts may be a gentler alternative.

DeLauer shifts the conversation away from fiber quantity to nutrient quality, arguing that the postbiotic effect of polyphenols may be more relevant for gut barrier integrity than sheer roughage. He ties this to the inflammation microplastics cause: even if particles get inside, a robust antioxidant defense can blunt their negative effects. Bright‑colored fruits and their extracts are his suggested sources, and he mentions that products like urolithin A (from his sponsor) are examples of postbiotics derived from polyphenols.

Mechanism

Polyphenols are metabolized by gut bacteria into bioactive compounds (postbiotics) that can strengthen tight junctions and reduce pro‑inflammatory signaling. Additionally, their antioxidant properties upregulate the body’s own antioxidant enzymes (superoxide dismutase, glutathione peroxidase) through the Nrf2 pathway, helping to quench oxidative stress triggered by microplastics. This dual action—local gut health plus systemic anti‑inflammation—addresses both absorption and the damage already done.

Polyphenols are both prebiotic and oftentimes postbiotic which means they encourage the good microbiome... they're also one of the most powerful things for overall anti-inflammatory effects within the gut.

Also said
“they also induce the indogenous anti-inflammatory effects within our body. So superoxide dismutase, glutathione peroxidase, which may even help us with the negative effects that have come from the microplastics in the first place from an inflammatory perspective.”— Directly links polyphenol metabolites to counteracting microplastic damage.

Hydration for Transit Time

WhatDrink more water throughout the day to improve gastrointestinal transit time and aid stool‑based microplastic excretion.
WhenDaily, consistently.
DoseNo specific volume; drink to ensure regular, soft bowel movements.
For whomAnyone, especially those with constipation or slow transit.
WhyAdequate hydration keeps stool soft and moving quickly, reducing time for potential re‑absorption of microplastics in the colon.
CaveatsOverhydration with electrolyte imbalance is possible; follow general hydration guidelines.

DeLauer emphasizes hydration as the simple, shockingly easy step that makes the other gut protocols work. Without enough water, soluble fiber can paradoxically cause constipation, and bile acid sequestration might be less effective. He repeatedly ties hydration to transit time, not just for general health but explicitly for flushing microplastics.

Mechanism

Water is absorbed in the small and large intestines; insufficient fluid leads to harder, slower‑moving stool, which can increase contact time between gut contents and the intestinal wall. Proper hydration maintains stool consistency and peristalsis, facilitating the elimination of bile acid‑bound microplastic complexes before they can be re‑absorbed.

Drink more water. How do we improve the gut barrier integrity? Glutamine, collagen, bone broth... Soluble fiber improves that bile acid sequestration. So it comes full circle back to gut health

Also said
“hydration comes into play there for sure. We definitely want to focus on that.”— Stresses hydration as an integral part of the protocol.

Stress Reduction and Avoid Over‑Exercising for Gut Health

WhatReduce psychological stress and avoid excessive exercise to protect gut barrier integrity.
WhenOngoing lifestyle practice.
DoseNo specific prescription; incorporate stress management techniques and moderate exercise.
For whomIndividuals under high stress or those with intense training regimens.
WhyChronic stress and over‑training can increase intestinal permeability and inflammation, undermining the gut barrier and making microplastic absorption more likely.
CaveatsNot elaborated in depth; mentioned as an additional supportive measure.

DeLauer lists stress reduction and not over‑exercising alongside dietary measures as real, actionable steps. He does not dive deep but implies that people often overlook lifestyle factors that directly impact gut permeability. The connection to microplastics is indirect: a healthier gut barrier reduces systemic absorption, so anything that weakens the barrier is counterproductive to the overall detox strategy.

Mechanism

Stress activates the hypothalamic‑pituitary‑adrenal axis and sympathetic nervous system, releasing cortisol and catecholamines that can disrupt tight junction proteins and reduce gut blood flow. Over‑exercising similarly can cause transient intestinal ischemia and inflammation, leading to leaky gut. By mitigating these stressors, gut barrier function is better preserved.

don't over exercise. Like these are real things.

What's new

Personal practice updates, fresh positions, predictions

3 items

Gut-first strategy as the best way to eliminate microplastics

around 2:00–4:00

DeLauer argues that because microplastic particles are found in stool and absorption occurs mainly via the gut, the most evidence‑backed way to reduce body burden is to optimize gut barrier integrity, bile acid sequestration, and transit time.

Why this matters: Synthesizes early research on microplastic excretion into a practical, gut‑centric protocol rather than focusing on avoidance alone.

Background

Prior advice on microplastics centered on reducing exposure (glass containers, filtering water, etc.), with little guidance on active elimination from the body once absorbed.

DeLauer points to a study in Total Environment showing every participant had microplastics in their stool, and another in International Journal of Pharmaceutics confirming that smaller particles are easier to absorb through the intestinal tract. This dual evidence suggests that while absorption is inevitable, excretion via stool is possible. He therefore shifts the focus from impossible‑to‑avoid exposure to maximizing what the body can eliminate through the gut. The overarching claim is not that all microplastics can be flushed out, but that reducing absorption and enhancing fecal excretion is the most promising route given current science.

So if I told you straight up that the best way to eliminate microplastics is through the gut. You could turn off the video because you know it's through the gut, but what are you going to really do? Like how are you going to learn how to do this?

Also said
“they found that every single subject in this study when they tested their stool they had varying levels of microplastics come out through their stool”— Shows that fecal excretion of microplastics is universal, not theoretical.
“the smaller the particle the easier it is to absorb. So through the intestinal tract they absorb and then they go into our bloodstream and they go into all tissues and organs.”— Explains why preventing small particle absorption is key.

Bile acid sequestration for microplastic removal

around 5:00–7:00

Soluble fiber increases bile acid flow, and bile acids can sequester fat‑soluble compounds including microplastics, carrying them out via stool.

Why this matters: Introduces a specific physiological mechanism (bile acid binding) as a practical detox tool, rather than generic fiber advice.

Background

Bile acid sequestrants are traditionally used to lower cholesterol; applying them to microplastics is a novel extrapolation.

DeLauer explains that bile acids normally aid fat digestion, but they also bind fat‑soluble toxins and now, by extension, microplastics. Consuming soluble fiber (chia, flax) increases bile acid synthesis and flow, and the fiber itself binds to bile acids, facilitating their excretion. This process, combined with hydration, helps ‘flush’ the bound particles out. He frames this as a full‑circle gut health strategy: protect the gut lining so fewer particles enter, and use bile acid sequestration to clear those already in the gut. He is careful to note this is early evidence and he cannot claim it removes microplastics from organs, only that it may reduce absorption and increase fecal elimination.

bile acid sequestration is where bile acids actually sequester some of the fat soluble things and even toxins in our gut and help move them out. So what you do is you use things like soluble fiber, chia seeds, flax seeds, anything with good amounts of soluble fiber and it increases because bile acid is actually going to bind to soluble fiber and it's going to help the flow of it.

Also said
“the bile acids are going to potentially bind to the nanoplastics, the microplastics and move it through the stool better along with proper hydration which is going to allow for the filtration.”— Directly links bile acids to microplastic binding.

Glutamine dose for gut barrier integrity in microplastic context

around 3:00–4:00

DeLauer specifically recommends 3–5 grams of glutamine every other day to maintain tight junctions and reduce absorption of microplastic particles.

Why this matters: Provides a concrete, evidence‑adjacent dosage for gut health that is rarely quantified in public advice, especially tied to microplastic prevention.

Background

Glutamine is known as a fuel for enterocytes, but mainstream advice often lacks a precise dose or frequency.

DeLauer acknowledges that glutamine has attracted concerns in some circles, yet he asserts its importance for gut barrier integrity. The every‑other‑day dosing is meant to support the intestinal lining without overdoing it. He links this directly to microplastics: a tighter gut barrier means fewer small particles leak into the bloodstream. Combined with collagen and bone broth, this trifecta is his primary gut‑tightening protocol. He does not claim it works perfectly but positions it as one of the few actionable steps based on how microplastics enter the body.

We want to consume 3 to five grams of glutamine probably every other day. And I know that people have concerns with it, but glutamine is important for gut barrier integrity.

Also said
“what we want to do is we need to a make sure our gut barrier is very tight. The tight junctions within our gut are the way they should be.”— Reinforces the rationale—tight junctions prevent absorption of larger particles.

Recommendations

Products, supplements, and tools mentioned in the episode

3 items

L-Glutamine Supplement

Supplement

Recommended as part of the gut barrier integrity protocol, dosing 3–5 grams every other day.

While no specific brand is mentioned, DeLauer explicitly advises taking L‑glutamine to support tight junctions in the gut lining, which is a key part of his microplastic reduction strategy. He acknowledges some people have concerns but stands by its importance for barrier integrity. This recommendation is purely functional and is presented alongside collagen and bone broth as a trio.

We want to consume 3 to five grams of glutamine probably every other day.

Find L-Glutamine

Collagen Supplement / Bone Broth

Supplement

Consumed as part of the gut‑tightening trio to improve gut barrier function.

DeLauer recommends collagen and bone broth as dietary staples for gut health. He doesn’t specify brands or dosages, leaving it to the listener to include them consistently. They provide the amino acids and glycosaminoglycans needed to repair the gut lining. Together with glutamine, this forms the foundation of his advice for preventing microplastic absorption.

We want to consume things like collagen. We want to consume things like bone broth.

Find Collagen

Chia Seeds / Flax Seeds (Soluble Fiber Sources)

Product

Recommended for their soluble fiber content to facilitate bile acid sequestration.

Both chia and flax seeds are presented as practical, readily available options to increase soluble fiber intake. DeLauer does not promote a specific brand but advises using them daily to bind bile acids and enhance microplastic excretion. They also provide omega‑3 fatty acids and lignans, though these are not discussed.

vs alternatives

Any soluble‑fiber‑rich food would work, but these are his named examples.

you use things like soluble fiber, chia seeds, flax seeds, anything with good amounts of soluble fiber

Find Chia
Disclosed sponsorships1speaker disclosed

Timeline Nutrition Urolithin A (Mitopure Berry Powder)

Supplement Sponsored · disclosed

DeLauer promotes this supplement for mitochondrial health as an example of a postbiotic polyphenol derivative, and mentions he personally mixes it into yogurt.

DisclosureSponsor of the video; discount link provided.

Timeline Nutrition’s patented form of urolithin A, called Mitopure, induces mitophagy—the selective degradation of damaged mitochondria—thereby improving mitochondrial quality and energy production. DeLauer states they have published in major peer‑reviewed journals (JAMMA implied). While not directly a microplastic detox supplement, he frames it as a postbiotic that supports overall cellular health, which can help the body cope with microplastic‑induced stress. The berry powder form is convenient and can be added to foods. His recommendation is backed by an offered discount.

Personal experience

I recommend just taking their berry powder form. I mix it in yogurt, all kinds of stuff. Makes it easy.

it's timeline nutrition and this patented form of uroliththn called mitoure is something that induces something called mphagy... They've been a sponsor on this channel for a while because I really support what they're doing and the research.

Also said
“They've got published in JAMAMA and all kinds of major peer-reviewed journals.”— Cites credibility of the product's research.
“It's probably one of the most promising things that's out there right now.”— Strong endorsement.
Find Timeline

Notable quotes

Lines worth pulling out — contrarian, specific, or perfectly phrased

5 items
So if I told you straight up that the best way to eliminate microplastics is through the gut. You could turn off the video because you know it's through the gut, but what are you going to really do? Like how are you going to learn how to do this?
Sets up the central thesis with a rhetorical hook, emphasizing that actionable detail matters more than the obvious statement.
polyorbate I'm just going to get on a limb and say it should probably never come in your body. Seeing how we use it in research settings to literally induce inflammation and lipopolyaccharides.
Strong, unequivocal stance on an additive, backed by a rarely‑mentioned research fact that builds trust.
I am not making a bold claim and saying you're not going to have microplastics. Okay? We're seeing them in the brain. We're seeing them in the heart. We're seeing them in the testes, the lungs, everywhere, all tissues.
Demonstrates scientific humility while underscoring the ubiquity of the problem, framing his advice as mitigation rather than cure.
it's less about the total amount of fiber and more about the quality of these polyphenols and these different antioxidant compounds.
A counterintuitive shift away from the common emphasis on fiber quantity, highlighting a more nuanced gut‑health strategy.
we're not going to change the environment so rapidly that we're not having microplastics everywhere.
A realistic acknowledgment that avoidance alone is impossible, justifying the need for internal defenses.

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Topics covered

microplasticsgut healthbile acid sequestrationgut barrier integritypolyorbatesemulsifierssoluble fiberpolyphenolsglutaminecollagenbone brothcolostrumhydrationtransit timepostbioticsmitophagyurolithin Ainflammationmitochondrial healthdetoxification
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Educational summary of the cited expert source — not medical advice. Open the source recording linked above and consult a qualified physician before acting on any protocol.