Jeff Bezos predicted to land Blue Origin's first unmanned cargo mission at Shackleton Crater on the Moon in 2026, beating SpaceX, while Elon Musk perfects orbital refueling for a Mars launch.
2
AI expected to surpass 90% on economic tasks benchmarks, potentially solving a Millennium Prize problem and passing the remote Turing test on Zoom—meaning indistinguishable from human co-workers.
3
Dave's 100x AI scaling via quantization, and Salem's AI-native rewrites will kill digital transformation, requiring 10–20x fewer employees and reshaping enterprises.
4
Breakthrough human trials for epigenetic age reversal by Life Biosciences (David Sinclair) begin in 2026, with a pill version in the works, pointing toward longevity escape velocity.
Protocols
Concrete recipes — what, when, how much, and why
4 items
AI-native edge team transformation
WhatInstead of transforming legacy systems, create a separate AI-first 'red team' that rebuilds your company's capabilities from scratch with AI, then replace the old organization.
WhenWhen your organization wants to genuinely leverage AI rather than bolt it onto existing human-centric processes.
For whomCEOs, transformation leaders, and decision-makers in established companies.
WhyAutomating human workflows with AI fails because it mirrors old bottlenecks; an AI-native rewrite yields 10–20× efficiency by removing the human from the middle.
CaveatsThe human role becomes oversight and exception handling; radical restructuring may face internal resistance. Consultants may be needed as scapegoats.
Salem uses the analogy of putting radio announcers on television to illustrate the futility of merely porting human processes to AI. The red team approach means a small, AI-first group builds a parallel capability on the edge, then supplants the legacy system. He believes this will become the dominant model in 2026 as the speed of AI makes human bottlenecks obvious. The consulting industry can pivot by staying a step ahead and advising on these rewrites, especially in public institutions.
Create an AI team ... build an equivalent capability like a red team kind of capability along the edge.
Also said
“AI won't destroy your company, but your org chart will if you don't do this.”— Adds urgency.
Intense burst startup commitment
WhatWork 100 hours a week, six days in-office for a 1–2 year period at an AI startup to capture life-changing equity.
WhenWhen joining a company that demands such commitment (e.g., Merkore), recognizing the narrow window of opportunity.
Dose100 hours/week, 6 days in-office, for a short period (1–2 years).
For whomAmbitious individuals without family baggage (young or those willing to sacrifice).
WhyThe window of opportunity for an AI startup is narrow; a short life commitment pays for the rest of your life through the upside generated.
CaveatsRequires spousal/partner buy-in; hard with young kids or established career paths. Not everyone can sustain it.
Salem recounts meeting two Merkore interviewees: the company filters for willingness to work 100-hour weeks. One person accepted after a tough conversation with his wife; the other said no way. Salem and Dave note this likely selects for single young individuals, but older people could do it if they shed inertia. The upside is unprecedented due to the speed of AI-driven wealth creation. This protocol is presented as an example of the extreme measures required to capture the fastest wealth creation in history.
Personal experience
I bumped into two people this week that are interviewing for jobs at Merkore... one said 'Yep, I'm doing it.' Had difficult conversation with his wife... the other said 'No way.'
Look, you have to commit to being in the office six days a week and working 100 hours a week. ... a lot of people just can't do that.
Also said
“The window of opportunity for what they're doing is so narrow. So it's a life commitment. You only have to do it for a short period of your life and the upside that you generate in that short period of your life, it pays for the rest of your life.”— Cost-benefit framing of the extreme commitment.
Hunt for emerging acronym sectors
WhatIdentify obscure new three- or four-letter technical acronyms (like RLHF) early and dive in to build or invest, as they can create billion-dollar companies within three years.
WhenContinuously monitor AI research and open-source projects for new jargon that signals an emerging industry.
For whomEntrepreneurs, investors, job seekers looking for asymmetric upside.
WhyLegacy businesses take decades to reach $10B valuation; these new acronym industries can do it in three years and mint young billionaires.
CaveatsRequires deep technical awareness and willingness to act before mainstream recognition; windows may be fleeting.
Dave illustrates with RLHF, which went from unknown to a multi-billion-dollar data labeling industry in three years. He expects a new equivalent acronym to emerge in 2026, creating at least one billionaire under 20. Immod agrees the speed of breakthrough-to-billion is unprecedented, and the market size is enormous. The implicit protocol is to stay on the bleeding edge, learn the jargon, and commit early.
RLHF would have sounded really weird to you three years ago when you wanted to jump in.
Also said
“You look at things that didn't exist in the world just a couple years prior and you see numbers ... two orders of three orders of magnitude bigger.”— The scale of opportunity in these obscure sectors.
Portfolio-based career proof
WhatReplace traditional resumes and credentials with a portfolio of actual projects (custom website, GitHub repos, artifacts you've built) to demonstrate capability.
WhenNow, when applying for jobs or seeking opportunities, especially in knowledge work.
DoseOngoing practice.
For whomJob seekers, freelancers, entrepreneurs, students—anyone looking to prove their value.
WhyKnowledge and capability are no longer institutionally gated; the market rewards what you can show, not what you studied.
CaveatsRequires initiative and execution; may not be accepted yet in highly regulated or conservative fields.
Salem's education prediction splits schools into credential factories and agency accelerators. In Silicon Valley, a developer's GitHub rating already matters more than a degree. Immod notes anyone can now build a customized website showing unique capabilities for a specific organization. The protocol is to create tangible proof and let the market judge, as the best protein folder in the world was a hairdresser discovered through performance, not credentials.
You replace credentials with portfolios of what you built and did.
Also said
“Why would you show a resume right now when you can show a customized website that you've built for someone showing your unique capabilities within their organization?”— Practical illustration of the principle.
What's new
Personal practice updates, fresh positions, predictions
6 items
Millennium Prize solved by AI
Alex predicts AI will solve one of the six remaining Millennium Prize problems in 2026, likely Navier-Stokes or the Riemann hypothesis.
Why this matters: AI cracking a grand challenge theorem would leap from pattern recognition to genuine mathematical discovery, changing the nature of mathematics.
Background
The Clay Mathematics Institute's Millennium Prizes are seven problems; only the Poincaré conjecture has been solved. Recent automatic theorem provers have shocked the field, e.g., solving Euler's problems.
Alex argues the multi-trillion-dollar question is whether compute can scalably convert into new discoveries. He notes Google DeepMind has a dedicated team of 12 on Navier-Stokes; xAI frequently discusses Riemann. Salem adds that AI might also prove another problem is ill-posed. The math community may dismiss the solution as 'brute force,' but the milestone would be undeniable. Immod emphasizes that the whole nature of math is changing because you can throw more and more compute at it from first principles. The prediction is a bet that 2026 is the year the goalposts can't easily be moved.
I think we're going to see one of the six remaining Millennium prizes from the Clay Mathematics Institute get solved by AI.
Also said
“Google DeepMind has a team reportedly of 12 people working on it. I know some of those people.”— Concrete evidence that major labs are targeting specific Millennium problems.
Quantization-driven 100x AI model growth
Dave predicts that FP4 and ternary quantization researched in chip-starved China will yield a 100x leap in effective model size and inference speed in 2026.
Why this matters: This would shatter existing exponential scaling, making 2026 a step-change year where speed translates directly to intelligence.
Background
Current models use FP16/BF16. Quantization reduces precision with minimal accuracy loss, allowing much larger models in the same hardware. China's chip embargo has forced extreme research into 1.58-bit ternary and FP4 representations.
Dave explains that both compressed weights and activations multiply inference speed, and speed means intelligence because post-training methods (bigger context windows, more thinking iterations) benefit. He argues that budgets, hardware, and algorithms are all growing, and quantization adds an underestimated multiplicative factor. Chinese labs are designing custom chips for ternary from scratch, giving them a temporary edge, but open-sourcing means the gains flow back globally. Immod adds that the practical limit may be 0.9 bits, so a 10–20× improvement is plausible, but Dave insists the combination of factors could hit 100×. The implication: year-end models will be 100× larger in parameter count and effective parameter flips during inference.
I think what we're going to see is more like a 100x year because people have underestimated quantization.
Also said
“Speed means intelligence. Those are interchangeable.”— Core rationale linking quantization to smarter models.
“What's happening right now is the Chinese because they're starved of chips are designing their own chips, building their own fabs, and they'll design those chips from the ground up to be FP4 and ternary.”— Mechanism showing how the embargo accidentally accelerates innovation.
Age reversal epigenetic reprogramming enters human trials
Peter predicts a 'Kittyhawk moment' in 2026 as Life Biosciences begins human trials of partial epigenetic reprogramming (three Yamanaka factors) to reverse aging in the eye and liver.
Why this matters: First clinical translation of Nobel-winning reprogramming biology from mice and primates to humans, with potential whole-body age reversal.
Background
Shinya Yamanaka discovered four factors (Oct4, Sox2, Klf4, c-Myc) that revert cells to pluripotency. David Sinclair found that omitting c-Myc (oncogenic) resets cells to a younger state without cancer. Preclinical work in non-human primates completed in 2025.
The initial human trials target NAION (a stroke in the eye) and then MASH (liver disease). Delivery uses AAV vectors (cost $500k–$1M), but Sinclair is developing a small-molecule pill that could cost a couple hundred dollars a month. Success would validate the platform for broader anti-aging. Peter links this to Kurzweil's longevity escape velocity prediction (early 2030s). Immod notes that health can now be scaled with compute, making it capital-dependent. Dave analogizes to AI's quiet 30-year acceleration before explosive mainstream attention, suggesting budget tipping points are near.
Kittyhawk moment for age reversal epigenetic reprogramming has been achieved.
Also said
“He thinks that the pill version of this ... could cost you a couple hundred bucks a month for age reversal.”— Highlights potential affordability and broad access.
Level 5 autonomy breakthrough in robots and cars
Immod predicts full Level 5 generalized autonomy in 2026 by leveraging massive cloud compute (10 million Blackwell GPUs), with meta-verifiers enabling superhuman navigation and task performance.
Why this matters: Level 5 autonomy means no human intervention required in any environment—a definitive arrival of fully autonomous physical AI.
Background
Self-driving cars are at Level 4 (geofenced); robots are ~Level 2. Sunday Robotics and others have shown progress in generalized assisted tasks, but unsupervised dexterity and navigation remain.
Immod argues edge compute isn't required first; cloud-scale training and verification can crack autonomy, then trickle down. He points to world models and reinforcement learning advances. Alex notes that government regulations will force companies to call it 'enhanced Level 4' even when technically Level 5, but special economic zones could unleash full autonomy. Dave is skeptical about robots due to dexterity and liability, but agrees cars will show Level 5 capability. The group highlights the wealth gap implications: the first households to own a robot will have a massive advantage, akin to early computer ownership in the 80s.
Level five automation and robots and cars breakthrough full generalized autonomy.
Also said
“I think if you've got enough chips, you've got a world model in a year.”— Explains the compute-world model link enabling Level 5.
“We're already drowning in world models there are world models getting launched several times per week at this point model scarcity is not one of the things I'd worry about.”— Alex's counter that world models are not the bottleneck.
Remote Turing test passed on Zoom
Immod predicts that in 2026 you won't be able to distinguish an AI from a human co-worker in everyday Zoom calls, because all technical pieces—video, speech, reasoning—have reached human level.
Why this matters: Blurs the line between human and AI workforce; remote-first companies will have AI team members indistinguishable from humans.
Background
Realistic AI avatars, dynamic speech synthesis, and low-latency reasoning now exist separately. Integrating them into a seamless conversation with natural interaction has been the missing piece.
Immod asserts that all the tech is already there; video generation, speech avatars, and reasoning are beyond human level. He expects full stack solutions (accountants, lawyers, marketers) to appear. Internally, companies won't require AI self-identification, so many new hires will effectively be AIs. Salem notes that state laws might mandate identification, but federal preemption could override; Alex jokes about asking the AI to say magic words. Peter foresees sending 'Peterbots' to meetings. The social contract remains undecided, but the prediction is a preference study will fail to tell the difference.
Remote touring test passed. Can't tell if a co-orker is an AI or a human on Zoom in daily life.
Also said
“You will see new employees entering your organization. You don't know if it's a human or an AI because doesn't really matter in that case.”— Practical workplace implication.
“I can generate a few dozen Peterbots and have them attend the meetings instead of me.”— Concrete anecdote encapsulating the prediction.
AI-native rewrites replace digital transformation
Salem predicts that companies will abandon decades-old digital transformation efforts and instead build AI-native edge teams that rewrite processes from scratch, using 10–20× fewer employees.
Why this matters: Signals the end of the multi-trillion-dollar systems integration and management consulting model as we know it.
Background
Digital transformation aimed to automate existing human workflows, often failing (the radio-announcer-on-TV analogy). AI makes the human bottleneck apparent, but many orgs still try to retrofit AI into legacy structures.
Salem argues that companies need a 'red team' approach: a small AI-first team that rebuilds core capabilities alongside the old organization. The human role shifts to oversight and exception handling. This AI-native rewrite will be 10–20× more labor-efficient and will take hold in 2026. When asked about consulting firms, Salem suggests they can survive by staying half a step ahead and helping public institutions transform—the 'land of the blind' effect. Immod quips that consultants become scapegoats but still lucrative. Salem adds that all our public institutions need rethinking, which is the biggest consulting opportunity ever.
Digital transformation in organizations is officially dead, replaced by AI native rewrites.
Also said
“Trying to fix your existing company just simply does not work in an age of AI because it's too humanentric.”— Core failure mode of current approaches.
“AI won't destroy your company, but your org chart will if you don't do this.”— Memorable warning.
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Also said
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