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Episode
Important OMAD Fasting Changes: We’ve All Been Making This Mistake
~48 min
Episode Brief·YouTube

Important OMAD Fasting Changes: We’ve All Been Making This Mistake

Thomas DeLauer
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TL;DR

The four things you'd lose by not watching

4 items

TL;DR

The four things you'd lose by not watching

4 items
1

OMAD works but carries risks of severe caloric restriction, nutrient deficiencies, and over-nutrition; fix them with a keto-friendly, calorie-dense meal of steak, eggs, olive oil, garlic, carrots, and broccoli.

2

Pair OMAD with keto because 23-hour fasting already produces ketones; carbs reduce caloric density and risk under-eating.

3

Supplement stack: 400-500 mg magnesium malate/glycinate for sleep, a probiotic for gut support, cod liver oil for omega-3s and vitamins A/D, CoQ10 for energy, 2-5 g creatine, and optional 5 g glutamine.

4

Thomas DeLauer recommends the Subco app (free via sup.co/thomas) for supplement trust scores and his curated fitness stacks.

Protocols

Concrete recipes — what, when, how much, and why

6 items

Magnesium for OMAD Sleep Support

WhatTake 400-500 mg of magnesium as magnesium malate or glycinate to improve sleep, which is often disrupted by fasting-induced adrenaline.
WhenWith the OMAD meal or before bed.
Dose400-500 mg daily
For whomOMAD practitioners experiencing sleep disturbances.
WhyFasting elevates adrenaline and can cause insomnia; magnesium promotes relaxation and sleep quality.
CaveatsAvoid oxide form (poor absorption); start with lower dose to assess bowel tolerance.
Mechanism

Magnesium acts as a GABA agonist and NMDA antagonist, reducing neural excitability. It also supports melatonin synthesis and relaxes muscles. The speaker recommends malate for energy support or glycinate for enhanced sleep, both more bioavailable than oxide.

I would recommend 4 to 500 millig of magnesium if you can in the form of magnesium malate or glycinate to help you sleep.

Probiotic for Gut Support on OMAD

WhatTake a probiotic supplement to bolster gut microbiota when eating one large meal daily.
WhenWith the OMAD meal.
DoseNot specified; follow label directions
For whomAnyone doing OMAD long-term.
WhyLarge infrequent meals challenge gut function; a probiotic helps ensure robust digestion and nutrient assimilation.
Mechanism

Probiotics introduce beneficial bacteria that can improve gut barrier integrity, aid in breaking down complex nutrients, and reduce inflammation from a large food bolus. The speaker implies this helps the gut “have a place to really work with” the incoming nutrients.

I would recommend a good probiotic when you're doing OMAD simply because just want to do what you can to support the gut.

Cod Liver Oil for Omega-3s and Fat-Soluble Vitamins

WhatSupplement with cod liver oil to provide omega-3 fatty acids, bioavailable retinol (vitamin A), and vitamin D.
WhenWith the OMAD meal (fat-soluble vitamins need dietary fat).
DoseNot specified; standard 1 tsp or as directed
For whomThose not regularly eating fatty fish, or wanting a comprehensive fat-soluble vitamin source.
WhyMany OMAD diets lack omega-3s; cod liver oil also delivers preformed vitamin A and D, which are critical for immune function and may be deficient on restrictive eating patterns.
CaveatsCheck for purity; not to be confused with fish oil (lower vitamins).
Mechanism

Omega-3s EPA/DHA dampen inflammation and support cell membranes. Retinol is crucial for vision, immune cell differentiation, and gene expression. Vitamin D modulates immune responses and calcium homeostasis. The combination ensures a broad anti-inflammatory and nutrient-dense addition to the OMAD meal.

I would recommend cod liver oil. That way you're getting omega-3s in, especially if you can't eat salmon or anything like that. But you're also getting bioavailable retinol A and vitamin D from cod liver oil.

CoQ10 for Energy and Electron Transport

WhatTake coenzyme Q10 to support mitochondrial energy production and improve fasting efficiency.
WhenWith the OMAD meal.
DoseNot specified; typical 100-200 mg
For whomAny OMAD practitioner, especially those feeling fatigued.
WhyCoQ10 is a cofactor in the electron transport chain, enhancing ATP synthesis. This helps maintain energy levels during prolonged daily fasts.
CaveatsConsult healthcare provider if on blood thinners.
Mechanism

CoQ10 shuttles electrons between complexes in the mitochondrial inner membrane, directly boosting ATP production. By improving cellular energy efficiency, it may offset the metabolic strain of fasting and support physical performance.

I would recommend co-enzyme Q10, CoQ10, so you can help out with that electron transport chain and help energy manufacturing throughout this process as well. It makes you more efficient at fasting.

Creatine for Strength and Muscle Volume

WhatConsume 2-5 grams of creatine monohydrate daily to maintain strength and intramuscular water retention during OMAD.
WhenAnytime, even during the fasting window; will not break a fast.
Dose2-5 grams per day
For whomThose engaged in resistance training while on OMAD.
WhyCreatine supports ATP regeneration for strength training, and its osmotic properties help preserve muscle fullness despite infrequent meals.
CaveatsSome individuals may experience mild bloating; ensure adequate hydration.
Mechanism

Creatine phosphate donates a phosphate group to ADP to rapidly regenerate ATP during high-intensity exercise. Additionally, creatine draws water into muscle cells, increasing cell volume which can signal anabolic pathways and counteract the catabolic stress of prolonged fasting.

maybe two to five grams of creatine to help you out with strength so that you can keep on kind of having this strength and muscle volume and water retention in the intramellular fiber.

Glutamine for Gut and Immune Support

WhatOptionally add 5 grams of glutamine to support gut lining integrity and immune function.
WhenWith or after the OMAD meal, or during the fast if well tolerated.
Dose5 grams
For whomThose with gut issues or immune system concerns on OMAD.
WhyFasting combined with large meals can stress the gut; glutamine is a primary fuel for enterocytes and helps maintain barrier function.
CaveatsGenerally well tolerated; start with lower dose if sensitive.
Mechanism

Glutamine is the most abundant amino acid and a key substrate for rapidly dividing cells like intestinal epithelial cells and immune cells. It helps preserve tight junction integrity, reducing intestinal permeability that might be exacerbated by prolonged fasting and sudden large meals.

if you're having gut issues or immune system issues, 5 g of glutamine might not be a bad idea as well.

What's new

Personal practice updates, fresh positions, predictions

3 items

omad-should-be-keto

DeLauer argues OMAD practitioners should follow a ketogenic diet to maintain ketosis, increase caloric density, and avoid under-eating.

Why this matters: Challenges the common OMAD approach of eating anything during the window, presenting a specific macronutrient strategy to mitigate risks.

Background

Typical OMAD advice allows any food, but many people fill up on low-calorie carbs, causing metabolic slowdown.

Since OMAD already involves 23 hours of fasting, the body is producing ketones. Switching to a ketogenic meal keeps the person in ketosis, which may enhance fat oxidation and mental clarity. More importantly, carbohydrate-rich meals are less calorie-dense per volume, making it harder to consume enough energy in one sitting. The speaker emphasizes that insufficient calories is a primary danger of OMAD, leading to a shrinking metabolic rate and stalled weight loss. By choosing fatty cuts of meat, eggs, and added oils, the dieter can hit calorie targets without excessive stomach distension. He also notes that keto eating spares protein for muscle maintenance and provides sustained energy. The argument is framed not as dogmatic keto promotion but as a pragmatic solution to OMAD's biggest pitfalls.

Because you're already fasting for 23ish hours with one meal a day. You're already producing ketones. So, you might as well just stay in ketosis rather than bumping yourself out by having carbohydrates during your one meal a day.

Also said
“Carbs do not have a lot of caloric density, which means you fill up precious space within your stomach, making it so that you're running the risk of reducing calories too much.”— Directly connects keto choice to the core risk of caloric insufficiency.

caloric-sufficiency-omad

The biggest responsibility in OMAD is consuming enough total calories to prevent metabolic slowdown.

Why this matters: Reframes OMAD as requiring deliberate caloric abundance, countering the intuitive notion that eating less accelerates weight loss.

Background

Many OMAD dieters inadvertently create a severe deficit by eating one small meal, causing adaptive thermogenesis and making future weight loss harder.

DeLauer identifies severe caloric restriction as the number one risk of OMAD. Over time, chronic under-eating down-regulates metabolic rate, leading to a plateau where further weight loss becomes extremely difficult. He warns that the body adapts by becoming more efficient with energy, which is the opposite of the desired fat-loss outcome. To prevent this, the meal must be structured to deliver substantial calories in a nutrient-dense format. The solution presented is a high-fat, moderate-protein meal with added monounsaturated oils and optional low-glycemic carbs, ensuring that the daily intake supports basal metabolic needs. He stresses that avoiding this trap is a non-negotiable part of sustainable OMAD.

Remember, one of the greatest responsibilities that you have with one meal a day fasting is getting enough calories.

Also said
“you're not getting enough calories because you're eating one meal a day and eventually you're shrinking your metabolic rate down and down and down until it's harder and harder and harder to lose weight.”— Explains the mechanism of metabolic adaptation from chronic undereating.

omad-meal-blueprint

A precise, evidence-based OMAD meal composition: 7-8 oz New York steak, 3-4 eggs, 4 tbsp olive oil, garlic, carrots, broccoli, plus optional sweet potato and berry dessert.

Why this matters: Moves beyond generic 'eat a big meal' to a researched combination that simultaneously addresses calories, protein, fats, micronutrients, gut health, and antioxidant protection.

Background

Many people doing OMAD eat random large meals that either lack diversity or overwhelm digestion, leading to deficiencies or assimilation issues.

The speaker details each component's role: steak provides zinc for immune support (critical during sustained fasting), heme iron for red blood cells, and moderate saturated fat for myelin and hormones without excess. Eggs contribute choline for brain acetylcholine synthesis and support HDL cholesterol to prevent fasting-induced hormone decline. Olive oil (4 tablespoons) supplies monounsaturated fats that improve insulin sensitivity and counteract oxidation from a large nutrient bolus. Garlic offers potent prebiotic fibers and antimicrobial compounds. Carrots deliver carotenoids (lutein, zeaxanthin) for eye health without problematic carb loads. Broccoli contributes sulforaphane to support liver detoxification pathways that process the incoming nutrients. Together, this meal is designed to hit calorie targets, provide broad micronutrient coverage, and avoid over-nutrition stress. Optional additions—sweet potato (resistant starch), berries (polyphenols, low glycemic), and a Greek yogurt dessert—round out the meal for those who want carbs or probiotics without derailing the benefits.

Personal experience

I'd probably do about three or four for my size is 180 lbs.

What I would usually recommend is 7 to eight ounces, about 200 grams or so of a moderately fatty cut of beef... some steak, eggs, olive oil, maybe some avocado, some broccoli, some garlic, and some carrots.

Also said
“broccoli is there for good reason because broccoli contains the sulfurophane... to help the liver deal with nutrients help potential detoxification mechanisms within the body”— Explains the specific functional reasoning behind the vegetable choice.
“carrots are there simply because the antioxidant profile of carrots... carotenoids like lutein and zeaxanthin really good for the eyes.”— Provides the eye-health rationale for including carrots.
Disclosed sponsorships1speaker disclosed

Subco App (Supplement Trust Score and Shopping)

Service Sponsored · disclosed

Mentioned as a tool to research supplement quality, compare rancidity/oxidation of fish oils, absorption of creatine, and to access DeLauer's personal supplement stacks.

DisclosureThomas DeLauer states he has created fitness supplement stacks on the app and collaborated with Subco, providing a custom link (sup.co/thomas).

The Subco app is highlighted because the supplement industry lacks regulation, making it difficult for consumers to identify high-quality, third-party-tested products. The app provides a trust score for various supplements, aggregates clinical data, and allows direct Amazon purchasing. DeLauer has contributed curated fitness stacks (pre-workout, recovery, sleep) that users can view for free. The app is positioned as a solution to the transparency problem and a time-saver for anyone serious about supplementation.

vs alternatives

Unlike general supplement review sites or Amazon reviews, the trust score consolidates data like oxidation levels for fish oils or clinicals for absorption, offering a more objective comparison.

Personal experience

I've created some cool stuff along with Subco... I can like load the ones that I recommend and people can see them.

This is the coolest app I have seen in a long time. I don't usually promote apps, but I've created some cool stuff along with Subco.

Also said
“It makes it so that you can research your supplements all in one place. They've provided this thing called a trust score.”— Describes the core feature.
“let's say you're searching for fish oil pills... and you want to know which ones have the least rancidity or the lowest oxidation.”— Concrete example of comparative data.
Find Subco

Notable quotes

Lines worth pulling out — contrarian, specific, or perfectly phrased

6 items
One meal a day works. It works really, really, really well, which is why people do it. But it comes with some inherent risks, which is why I usually advise people don't do it for long.
Captures the love/hate relationship with OMAD and the urgency behind the message.
Because you're already fasting for 23ish hours with one meal a day. You're already producing ketones. So, you might as well just stay in ketosis rather than bumping yourself out by having carbohydrates during your one meal a day.
Succinct, contrarian logic that redefines OMAD as an inherently keto state.
Remember, one of the greatest responsibilities that you have with one meal a day fasting is getting enough calories.
Flips the typical dieting script and makes a bold, actionable statement.
your immune system can become suppressed because that's a lot of stress on the body. So zinc is very important for the immune system.
Draws a direct line from fasting to immune risk, justifying the steak choice.
I want your saturated fat to end up being about 20 to 30% of your total fat content.
Gives a specific ratio that shows the meal design is mathematically considered.
broccoli is there for good reason because broccoli contains the sulfurophane... to help the liver deal with nutrients help potential detoxification mechanisms within the body
Highlights the purposeful, functional inclusion of a vegetable beyond generic health advice.

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Topics covered

omadone-meal-a-dayfastingketoketosiscaloric-restrictionmetabolic-ratenutrient-deficienciesover-nutritionassimilationsteakeggscholineolive-oilmonounsaturated-fatsgarlicprebioticscarrotscarotenoidsbroccoli
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