Strength Training with 5-8 Reps and Two Reps in Reserve
Sims pushes back against the pervasive idea that women — especially aging women — need to do moderate-weight, high-rep training to 'tone' or avoid bulk. She reframes the goal: instead of chasing metabolic stress (the burn, the pump, the smashed feeling), women over 40 should pursue neuromuscular power and strength adaptations that produce a favorable hormonal environment. The reasoning is biological: with declining estrogen pulses, the post-exercise recovery landscape shifts, and the body leans heavily on testosterone and growth hormone. Heavy, low-rep work (5-8 reps) with a true load elicits a central nervous system response that stimulates these hormones, dropping cortisol and inducing relaxation. Higher rep sets (10-12) create metabolic stress but lack the same hormonal cascade, often leaving women exhausted, achy, and with elevated cortisol. By keeping reps under 8 and using RIR 2, she says you hit the sweet spot for strength and recovery every session. Moreover, she emphasizes that all the programming complexity people love — waves, clusters, de-loads — can and should be done inside this low-rep universe, so you never need to venture into the 10-12 range.
Resistance exercise is a stressor that damages muscle tissue and activates the sympathetic nervous system. In response, the body releases anabolic hormones to repair tissue and reduce stress. In perimenopausal and postmenopausal women, the normal pulsatile signaling from estrogen is diminished, so the body compensates by upregulating testosterone and growth hormone. Low-rep, heavy lifting (CNS-driven) triggers a significant release of both. Testosterone helps counter the exercise-induced cortisol spike, while growth hormone drives tissue repair and remodeling. The combination lowers overall cortisol and allows a shift into a parasympathetic state, which is why women feel energized and clear-headed after the workout rather than wrecked. Higher reps (10-12) produce lactic acid and metabolic stress but a less pronounced testosterone/GH pulse, leaving a cortisol-dominant and fatigued state.
You don't ever want to go over eight. ... I say, okay, you want to go in and you want to look at doing your weights with two reps in reserve. ... Don't go over the eight.

