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Episode
World's #1 Anti-Wrinkle Cream
~12 min
Episode Brief·YouTube

World's #1 Anti-Wrinkle Cream

Brad Stanfield
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TL;DR

The four things you'd lose by not watching

4 items

TL;DR

The four things you'd lose by not watching

4 items
1

Sunscreen is the #1 anti-aging cream: a 2013 trial showed daily use prevented skin aging for 4.5 years, and a 2016 follow-up even showed reversal.

2

The rise in skin cancer despite more sunscreen use is explained by increased sun exposure when wearing sunscreen, inadequate application, and an aging population—not sunscreen failure.

3

Chemical sunscreen ingredients can be absorbed through skin above FDA safety thresholds, but evidence of harm is unclear; the speaker avoids older chemical sunscreens and prefers mineral or newer, larger-molecule chemicals like triazorb and bermatresinol.

4

The US FDA hasn't approved a new sunscreen ingredient since 1999, while the EU and Australia have adopted safer, non-absorbing chemicals; Bemotrizinol may be FDA-approved by year's end.

Protocols

Concrete recipes — what, when, how much, and why

2 items

Daily broad-spectrum sunscreen SPF 50+

WhatApply a sunscreen labeled broad-spectrum with SPF 50 or higher every day.
WhenDaily, before sun exposure.
DoseAdequate amount (most people under-apply); reapply as needed. No exact volume given.
For whomEveryone, especially those concerned about skin aging and cancer.
WhyDaily use stops UV-induced collagen and elastin breakdown, DNA damage, and pigment cell stimulation, preventing and even reversing skin aging; reduces skin cancer risk.
CaveatsInadequate application leads to under-protection and false sense of security. Chemical sunscreens may be absorbed; mineral ones can leave white cast.

The speaker lays out the evidence for this protocol in detail. He references a landmark 2013 trial of 93 adults where daily sunscreen users showed no detectable skin aging after 4.5 years. A 2016 follow-up not only halted aging but demonstrated reversal of existing signs. He also points to a meta-analysis concluding that the highest-quality evidence indicates sunscreens prevent skin cancer. The mechanistic explanation covers visible light and UV radiation's effects: UV breaks down collagen and elastin, damages DNA, and overstimulates melanocytes, causing age spots. The sunscreen acts like a guard wall. The protocol is backed by a dramatic anecdotal photo: a 92-year-old who applied sunscreen to her face but not her neck for 40 years. The speaker frames this as the single most powerful anti-aging intervention, calling sunscreen 'the number one anti-aging cream.'

Mechanism

UV radiation degrades collagen and elastin, eroding skin firmness and elasticity. It also causes DNA mutations and activates pigment cells, leading to discolorations and accelerating visible aging. Sunscreen blocks UVA and UVB, reducing these insults.

In a landmark 2013 trial of 93 adults, the group who used sunscreen everyday didn't show any signs of skin aging after 4 and / or 5 years. A follow-up study in 2016 showed that sunscreen not only stopped the signs of skin aging, but it could even reverse them.

Also said
“It's like having a wall that guards the health of our skin from attacks that can damage us.”— Metaphor for how consistent use prevents accumulated damage.

Choose sunscreen without the 12 FDA-flagged chemical ingredients

WhatAvoid older chemical sunscreens containing the 12 active ingredients the FDA has asked more safety data for. Prefer either 100% mineral sunscreens (zinc oxide, titanium dioxide) or sunscreens using newer, large-molecule chemical filters (like triazorb, beanol, bermatresinol).
WhenWhen purchasing sunscreen.
For whomAnyone concerned about potential long-term effects of synthetic chemical absorption.
WhyOlder chemical ingredients are absorbed into the bloodstream above FDA thresholds, and some evidence suggests hormone disruption; mineral and newer large-molecule chemicals minimize systemic absorption.
CaveatsMineral sunscreens can leave a white haze and resist water less well. Availability of newer chemical filters is limited in regions where they haven't been approved (e.g., the US, where no new sunscreen ingredient has been approved since 1999).

The speaker details the absorption problem: a 2020 study found all six tested active chemical sunscreen ingredients entered the bloodstream at levels exceeding the FDA's safety benchmarks. He stresses the study didn't prove harm, only absorption. However, he cites a 2017 review and a 2024 meta-analysis suggesting some ingredients may disrupt hormones and cause developmental issues, though the evidence is largely from animal studies at high doses. The FDA consequently requested more safety data on 12 common ingredients. The speaker interprets this uncertainty personally, opting to avoid those ingredients. He then presents mineral formulations as safe (zinc oxide and titanium dioxide are not absorbed) but acknowledges their aesthetic and water-resistance drawbacks. The protocol resolves the dilemma by adding a new class of chemical filters that are too large to penetrate skin, offering the elegance of chemical sunscreens without the absorption. He gives specific acceptable ingredient names and brands.

Mechanism

Chemical sunscreens absorb UV and convert it to heat, but their small molecular size allows transdermal absorption into the bloodstream. Mineral blockers sit on top and physically reflect/scatter UV. Newer chemical ingredients like triazorb and beanol are engineered to be larger molecules, thus unable to pass through the skin barrier.

Personal experience

Personally, I don't want to be putting chemicals on my skin when I'm not sure what their long-term effects might be. This is particularly true when we've got some reasons to suspect that they're not good.

It's important to choose a sunscreen that's got a broadspectctrum protection… when it comes to the sun protection factor or SPF, we want to shoot for at least 50 for maximum effectiveness. One option that does meet all of these requirements that I want in a sunscreen is Caravee 100% Mineral Sunscreen SPF 50. It has both titanium dioxide and zinc oxide and none of the other 12 flagged ingredients from the FDA.

Also said
“Mineral sunscreens are the safest, having the fewest potential adverse effects.”— Summarizes a 2024 study conclusion that supports the mineral half of the protocol.

What's new

Personal practice updates, fresh positions, predictions

3 items

New sunscreen chemicals solve absorption concerns

Large-molecule UV filters like triazorb and beanol (bermatresinol) have limited skin absorption, broad-spectrum coverage, and high photostability, eliminating the safety worries of older chemical sunscreens.

Why this matters: These ingredients represent a breakthrough that could end the trade-off between safety and cosmetic elegance, but many consumers can't access them yet.

Background

Traditional chemical sunscreens (the kind widely available in the US) use smaller molecules that penetrate the skin and appear in the bloodstream at levels above FDA thresholds, raising hormonal concerns. Mineral alternatives like zinc oxide sit on the surface but leave a white cast and don't hold up well in water.

The transcript presents newer chemical sunscreen agents as a third way. Triazorb and beanol are introduced as examples of modern filters that are large enough to prevent skin penetration while still providing broad-spectrum UV protection and resisting degradation in sunlight. The speaker emphasizes that these compounds are already approved and in widespread use in the European Union and Australia, where regulators have been more proactive. He notes that they are 'potentially safer with much lower absorption rates' and 'have a broader range of UV coverage' than traditional options. The implication is that if you live in a jurisdiction where these are available, you can get high-protection sunscreens without the residue of minerals or the absorption risk of older chemicals.

The speaker presents this as essentially solving the sunscreen safety-versus-usability dilemma. He laments that the US FDA hasn't approved any new sunscreen ingredient since 1999, leaving Americans stuck with older formulas. However, he adds hopeful news: bermatresinol (Bemotrizinol) is currently under FDA review and has been thoroughly tested in other countries; approval is expected by the end of the year. The section frames a regulatory gap that has kept a superior generation of sunscreens out of reach for many consumers.

Scientists have developed new compounds that are superior to the traditional options. So, one of the most recent is triazorb. This chemical has two very attractive qualities. First, it absorbs UV radiation across a wide spectrum. And second is that it's relatively large, so it doesn't penetrate through the skin.

Also said
“Now, compared to traditional options, these newer sunscreen chemicals are a huge improvement. They're potentially safer with much lower absorption rates. They also have a broader range of UV coverage, and they are more stable when exposed to light, so they maintain their effectiveness for longer.”— Explicitly contrasts the performance and safety advantages over legacy chemical sunscreens.
“The European Union and Australia, for example, they've been proactive in adopting the newer chemical ingredients with a better safety profile. But many other places lag behind. So, in the US, for example, the FDA hasn't added any new sunscreen ingredients to its approved list since 1999.”— Highlights the regulatory divide that makes this innovation inaccessible to many.
“Bmatresinol is currently under review by the FDA. It's been in use for a long time in England, Australia, and the European Union, and it's been thoroughly tested. It's hoped that it will be approved by the end of this year.”— Provides the concrete upcoming milestone for US consumers.

Personal shift to newer Korean and mineral sunscreens

The speaker now uses a Beauty of Joseon sunscreen containing newer chemical ingredients, or would fall back to CeraVe mineral sunscreen, explicitly avoiding the 12 FDA-flagged ingredients.

Why this matters: It's a specific, actionable personal practice change based on the evolving evidence about absorption and safety.

Background

Previously, many people (including the speaker presumably) might have used whatever sunscreen was readily available without scrutinizing ingredient absorption profiles.

The speaker describes wrestling with the uncertainty around older chemical sunscreens. While acknowledging that the data don't prove harm, he states a personal decision: 'I don't want to be putting chemicals on my skin when I'm not sure what their long-term effects might be. This is particularly true when we've got some reasons to suspect that they're not good.' He then explains that living in New Zealand gives him access to sunscreens using newer, non-absorbing chemicals like bermatresinol, pointing to four Korean brands (the one he uses is Beauty of Joseon). For those without such access, he recommends CeraVe 100% Mineral Sunscreen SPF 50, which contains only zinc oxide and titanium dioxide and none of the FDA-flagged ingredients. He makes clear that this is his own risk calculus, not a universal directive, but the shift is clearly tied to the emerging data on absorption.

Personal experience

I'm lucky enough to live in New Zealand, I've got access to sunscreens that don't have any of those 12 flagged ingredients by the FDA and instead they use newer chemical ingredients like bermatresinol. ... The one I'm using at the moment is beauty of join [Beauty of Joseon]

I don't want to be putting chemicals on my skin when I'm not sure what their long-term effects might be. This is particularly true when we've got some reasons to suspect that they're not good.

Also said
“If I didn't have access to those sunscreens, I would use Saravee [CeraVe] 100% mineral sunscreen SPF 50. Again, this is my own personal decision, but until we've got more data, I do want to stay away from those 12 flagged ingredients.”— Clarifies his backup choice and the personal, precautionary nature of the decision.

Cancer rise despite more sunscreen is explained by behavior and demographics

The claim that sunscreen fails because skin cancer rates are climbing along with usage is rebutted by citing inadequate application, riskier sun exposure due to a false sense of protection, and an aging population.

Why this matters: Counters a popular internet skepticism about sunscreen efficacy with specific mechanisms.

Background

Sunscreen critics often point to rising melanoma diagnoses as proof that sunscreen doesn't work. The transcript lays out this claim explicitly.

The speaker acknowledges the data points: sunscreen use in the US rose from 25% to 33% since 2000, while melanoma rates are climbing. He says the conclusion that sunscreen is useless is wrong. Instead, he offers three explanations. First, sunscreen users tend to stay in the sun longer because they feel protected, yet most apply too little, resulting in higher cumulative UV damage. Second, the population is getting older; peak melanoma diagnoses occur in the 70s, so an aging demographic alone pushes incidence numbers up. Third, he stresses that the causal chain—UV radiation causing skin cancer—is not in dispute, and properly used sunscreen greatly reduces UV exposure. The argument is that the observational trend is confounded, not that the intervention fails.

We should be very skeptical of claims that using sunscreens aren't doing us any good.

Also said
“For one thing, when people wear sunscreen, they tend to spend more time in the sun. This is because they feel protected and yet most people don't use an adequate amount of sunscreen. So they end up with higher levels of damaging exposure.”— Explains the behavioral confounder.
“Another key factor is an aging population. People are having fewer kids and living longer, shifting the proportion of people over 65 upward. This is important because skin cancers are much more common the older that we get.”— Presents the demographic confounder that can account for rising incidence.

Recommendations

Products, supplements, and tools mentioned in the episode

1 item

CeraVe 100% Mineral Sunscreen SPF 50

Product

For consumers in regions where newer chemical filters are not approved (like the US), this mineral sunscreen provides broad-spectrum SPF 50 with only zinc oxide and titanium dioxide—no FDA-flagged chemical ingredients—though it may leave a white residue and is less water-resistant.

The speaker presents CeraVe 100% Mineral Sunscreen as the best fallback for those who cannot purchase the new-generation Korean or European chemical sunscreens. He notes it meets his criteria of broad-spectrum, SPF 50+, and contains none of the 12 ingredients the FDA has flagged for further safety evaluation. While acknowledging the cosmetic downsides (white haze, water resistance not as good as chemical formulas), he frames this as an acceptable trade-off for safety. The recommendation is clearly targeted at a US audience or anyone without access to bermatresinol-containing products, and he states he personally would use it if he didn't live in New Zealand.

vs alternatives

Vs. traditional US chemical sunscreens: eliminates systemic absorption of the 12 flagged ingredients. Vs. newer chemical sunscreens: inferior cosmetic elegance and water resistance, but equal safety profile.

Personal experience

If I didn't have access to those sunscreens, I would use Saravee [CeraVe] 100% mineral sunscreen SPF 50.

One option that does meet all of these requirements that I want in a sunscreen is Caravee [CeraVe] 100% Mineral Sunscreen SPF 50. It has both titanium dioxide and zinc oxide and none of the other 12 flagged ingredients from the FDA.

Also said
“The two most common ingredients used here are zinc oxide and titanium dioxide. These compounds are not absorbed through the skin.”— Reinforces the safety rationale for this mineral sunscreen.
Find CeraVe
Disclosed sponsorships1speaker disclosed

Beauty of Joseon Sunscreen (with newer chemical ingredients like bermatresinol)

Product Sponsored · disclosed

For those with access to non-US markets (e.g., New Zealand, EU, Australia), Korean sunscreens using newer, non-absorbing chemical filters offer broad-spectrum SPF 50+ without the white cast of minerals or the absorption concerns of older chemicals.

DisclosureSpeaker states no affiliation with the brand; mentions he personally uses it.

The speaker explains that he lives in New Zealand and therefore can purchase sunscreens formulated with molecules like bermatresinol that are not yet available in the US. He lists four Korean brands on screen, but only names the one he uses: Beauty of Joseon. He positions this as an elegant solution that combines the cosmetic acceptability of traditional chemical sunscreens with the safety profile of minerals, because the active ingredients are too large to pass through the skin. The recommendation is conditional on geographic availability and the consumer's desire to avoid the 12 FDA-flagged ingredients. He emphasizes it is his personal choice, not a blanket endorsement, but the clear implication is that if you can get it, it's a top-tier option.

vs alternatives

Compared to CeraVe mineral sunscreen, it provides the same level of safety (no absorption, no flagged ingredients) without the white residue and water-resistance trade-off. Compared to older US chemical sunscreens, it eliminates the absorption and hormone-disruption unknowns.

Personal experience

The one I'm using at the moment is beauty of join [Beauty of Joseon], but any of these four options are a great choice.

Since I'm lucky enough to live in New Zealand, I've got access to sunscreens that don't have any of those 12 flagged ingredients by the FDA and instead they use newer chemical ingredients like bermatresinol. ... The one I'm using at the moment is beauty of join [Beauty of Joseon].

Also said
“There are four famous Korean brands and I'm not affiliated with any of them that are great options and I'll put them on the screen now.”— Confirms the non-affiliation and that multiple acceptable products exist.
Find Beauty

Notable quotes

Lines worth pulling out — contrarian, specific, or perfectly phrased

5 items
Sunscreen is the number one anti-aging cream.
Memorable, declarative headline that sums up the entire video's thesis.
We should be very skeptical of claims that using sunscreens aren't doing us any good.
Directly counters social-media narratives that dismiss sunscreen; frames the rebuttal.
Whether concentrations that result from daily use or environmental contacts possess a realistic hazard to humans and other organisms is still unknown.
Candid admission of the genuine scientific uncertainty around chemical sunscreen safety.
The US FDA hasn't added any new sunscreen ingredients to its approved list since 1999.
Stark fact highlighting regulatory stagnation that limits US consumer options.
I don't want to be putting chemicals on my skin when I'm not sure what their long-term effects might be. This is particularly true when we've got some reasons to suspect that they're not good.
Crisp personal decision statement that many viewers will identify with.

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Topics covered

sunscreenanti-aginguv-radiationskin-agingskin-cancersunscreen-controversychemical-sunscreenmineral-sunscreenabsorptionhormone-disruptionfda-regulationnew-sunscreen-ingredientstriazorbbeanolbermatresinolceravebeauty-of-joseonspfbroad-spectrumaging-population
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