Young Plasma, Peptides & Regeneration: My 3-Day Health Reset

Dr. Conwen explained that therapeutic plasma exchange (TPE) has been used since the 1920s and FDA-approved since 1939, but typical TPE replaces with albumin, not young plasma. The young plasma approach is based on parabiosis research showing old mice given young blood become physically and cognitively younger. The 3-day protocol produces a gradual shift: first day dilutes old plasma with IV fluids to soften the impact, then young plasma is infused over two days to steeply shift the signaling environment. Patients report immediate energy and mental sharpness; a 70-year-old high-stress executive called to say his 'brain was on fire' and he'd been up since 5 a.m. with productivity. The clinic is part of the Golden Gift Study to measure epigenetic age changes pre and post procedure. Volume matters: the full protocol (2L out, 3L in) gives better results than a 'media change' of just 1L.

Dr. Conwen notes this stack yields rapid results; Ben experienced a spontaneous erection hours later. He also uses shockwave and PRP to treat Peyronie's disease by breaking down scar tissue. Botox is often misunderstood as dangerous, but he argues it simply opens the vascular gate, and the increased resting girth is a welcome side effect. Red light therapy on the penis is used as a home maintenance tool. The entire protocol is performed under local numbing, described as 1-2 out of 10 discomfort.

Dr. Conwen explained that Korea is the centre of aesthetic innovation and this salmon sperm treatment is a highly sought-after procedure there. The clinic integrates it as the finishing layer after more intensive injectables. He personally tried it on his face to validate safety and efficacy. The treatment is separate from the P-Shot or genital applications. He views it as part of an annual maintenance strategy for skin.

Dr. Conwen was trained under Dr. Charles Runels, inventor of the P-Shot and O-Shot. He describes the O-Shot as the functional equivalent of the P-Shot for women, targeting the G-spot and clitoris. There is also an aesthetic-only 'wings lift' for labia using a thin mixture of PRP and filler for instant natural lift. Dr. Conwen tested the O-Shot on himself with a mirror to understand the experience.

Dr. Conwen cites the case of an ALS patient whose report lit up all neural-related pathways as abnormal, guiding the peptide design. He sees this as the next evolution beyond generic peptides like BPC-157, offering a truly tailored approach. The company uses a compounding pharmacy for production, and the doctor can layer in exosome delivery or other known peptides. He stresses that it's still early but extremely promising alongside plasma exchange.

Dr. Conwen detailed that plasma constitutes 52-55% of whole blood and contains over 10,000 proteins, 5,000+ peptides (including LL-37 and growth factors), and massive amounts of exosomes. The clinic sources plasma from pre-qualified college students aged 18-25, tested for the same pathogens as standard blood transfusions. The full protocol removes 2 liters of the patient's old plasma over two days and replaces it with 3 liters of young donor plasma, inducing a systemic ‘reset’ that he and his patients describe as a surge of energy, mental clarity, and reduced inflammation. He argues that the young plasma's exosomes and chronocines influence the recipient's epigenetic expression, not just passive replacement, and that the effect is systemic – hair, skin, and cognition improve.

Botox works by relaxing the smooth muscle that surrounds blood vessels in the penis, acting like opening a gate for blood inflow. This is distinct from direct vasodilators like Viagra or from the tissue-regrowing effect of PRP. The result is not only better erections but also an increase in resting flaccid size and girth because more blood remains in the tissue. Conwen pairs it with shockwave therapy (sound waves creating micro-injuries that trigger repair) and red light therapy as a post-treatment accelerator. He screened Ben for cardiovascular risk because ED can be an early sign of heart disease.

The treatment is part of the full 'region faceelift' where young plasma, exosomes, and laser-activated PRP are first injected, then micro-needling is performed to create tiny channels, and salmon sperm DNA is applied topically to absorb deeply. Conwen noted that males produce abundant sperm so sustainability isn't a concern. He recommends this once a year or every 3 months for maintenance. He distinguishes it from the P-Shot; salmon sperm is not used on genitals.

After testing, the platform highlights pathways related to the eight hallmarks of aging (mitochondria, inflammation, DNA stability, microbiome, etc.) and ranks the most problematic ones. For an ALS patient, all neural-related pathways lit up abnormal. The peptide mixture is then formulated, sent to the patient as 120 frozen vials, and injected twice weekly. Conwen can add exosome delivery or augment with known peptides like SS-31 or clot (cloth?) to stack effects.