Heavy CNS-focused strength training (experienced women)
Sims explains that earlier in life, women had a powerful hormonal environment for building lean mass and generating power. With perimenopause, that internal stimulus disappears, and traditional moderate reps become insufficient for meaningful adaptation. The alternative is to present an external challenge so demanding that the nervous system compensates. She prescribes failing at 5 reps — a rep range that maximally recruits high-threshold motor units. Cluster sets, where you break the volume into smaller chunks with short rest, allow you to lift heavier loads without excessive fatigue, making the approach sustainable. The ultimate purpose is not aesthetic but functional: preserving the ability to live independently at 80, 90, and beyond.
Estrogen enhances contractile speed, muscle protein synthesis, and motor unit recruitment. When estrogen declines, the body loses this internal signal for muscle adaptation. By applying a mechanical overload that brings muscles to failure within five reps, the CNS is forced to increase neural drive: greater motor unit synchronization, faster rate coding, and activation of high-threshold fibers. This neural upregulation can stimulate myofibrillar hypertrophy and strength gains independent of systemic estrogen, effectively creating a new pathway to maintain muscle mass and function.
So if we're looking at lifting heavy loads that we're failing by the fifth then we're really instigating central nervous system to say, 'Hey, wait, I need to have more nerve patterns and nerve conduction to be able to stimulate these muscle fibers and to actually create more muscle fibers to lift this load.'

