Episode

Episode Brief·YouTube

The Single Number That Tells You How Your Body Is Really Aging

Ben Greenfield

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TL;DR

The four things you'd lose by not watching

4 items

TL;DR

The four things you'd lose by not watching

4 items

Jimmy St. Louis’s company, Agentus, created the Longevity Quotient (LQ) — a 12–15 minute, 5-test battery (questionnaires, InBody scan, cognitive test, grip strength, blood labs) that produces a single score to gamify health and track biological aging.

He healed a partially torn ACL with repeated stem cell injections, confirmed by before-and-after MRIs, and later used intraosseous needling with bone marrow to reverse knee arthritis.

Ben Greenfield discovered that stacking an NAD IV with a Niogen IV (a brain-penetrating NAD precursor) delivers an immediate body-and-brain energy surge, whereas NAD alone did little for him.

Ben and Jimmy are co-designing a 12-week exercise protocol to integrate with Agentus’s LQ and clinic treatments, closing the gap between medical optimization and fitness.

Recommendations

Products, supplements, and tools mentioned in the episode

1 item

NAD+ and Niogen IV therapies

Supplement

IV NAD+ drips are common in longevity clinics; Niogen is a precursor (possibly nicotinamide riboside) that Ben and Jimmy stacked for enhanced effect.

Ben found that Niogen alone gave an immediate energy lift, and stacking with NAD produced a pronounced brain-body boost. The stack is available at the Nashville clinic and likely others in the Agentus network.

vs alternatives

Compared to oral NR or NMN, IV delivery bypasses gut absorption and first-pass metabolism; Niogen may be more brain-bioavailable than NAD itself.

Personal experience

Ben: 'I've actually found that energy levels after Niogen increased almost immediately... I really didn't notice a ton of difference... NAD IV and then you did a Niogen IV. And that stack was was pretty cool.'

I think maybe that that form, if I recall properly, gets into the brain better. So you get like a body plus brain boost from doing doing that stack.

Find NAD+

Disclosed sponsorships1speaker disclosed

Agentus longevity clinics

Service Sponsored · disclosed

Agentus clinics offer a honeycomb of services: hormone optimization, peptide therapy, biologics (stem cells, exosomes), IV therapy, advanced therapeutics (therapeutic plasma exchange), and modalities (red light, hyperbaric, infrared sauna, cryotherapy). Onboarding begins with the LQ, and care plans are protocolized with AI assistance.

DisclosureJimmy St. Louis is the founder of Agentus; Ben Greenfield is developing an exercise program for them.

The chain was built by acquiring top-performing clinics in different regions and service niches. For instance, some clinics excelled in hormone therapy, others in advanced biologics. By cross-pollinating best practices and using a centralized team of medical advisors (e.g., Matt Cook for peptides), Agentus creates consistent, evidence-guided protocols across locations while retaining local flavor. Not all locations offer all services; they segment into 'reclaimers' (those who want to regain lost ground) and 'achievers' (high-end optimizers). Cash-pay model aligns incentives, and the LQ plus wearables create a continuous data loop.

vs alternatives

Unlike conventional medical spas that offer a grab-bag of treatments without a overarching score, Agentus systematizes care behind a unified, tracked metric.

Personal experience

Ben visited the Nashville clinic and tried cryo, red light, ozone, exosomes, and Niogen.

Our goal is to share those best practices. So, our different treatment verticals or one is hormone therapy and be really good at that. The next is peptide therapies... then it's biologics, stem cell treatment, exoomes... Then there's the advanced therapeutics like therapeutic plasma exchange... Then there's the modalities and that's hyperaric and red light.

Also said

“Nobody had really defined the standard of care in the longevity space, but the consumer journey in my perspective is fragmented, confusing...”— States the core problem Agentus solves.

Find Agentus

Notable quotes

Lines worth pulling out — contrarian, specific, or perfectly phrased

5 items

We created this concept of the longevity quotient which is a series of five tests takes 12 to 15 minutes to complete.

The precise definition of the LQ, the episode’s central hook.

Grip strength I mean is what people may not know is probably the most measured marker for longevity, right?

A pithy summary of why grip strength belongs in a longevity battery.

I actually started doing stem cell treatment on it and was just doing joint injections and did before and after MRIs and I actually saw a physical change in the ACL being more and more intact.

A concrete, personal outcome illustrating potential of orthobiologics.

It was called intraosius needling where you like drill holes in the two articulating surfaces almost like airrating a lawn and then you plug up those surfaces... bone marrow based stem cell matrix.

Vivid description of an advanced cartilage restoration technique.

I think maybe that that form, if I recall properly, gets into the brain better. So you get like a body plus brain boost from doing doing that stack.

Explains the rationale behind the NAD+Niogen stack.

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Topics covered

longevity-quotientagentus-clinicsstem-cellsacl-recoveryintraosseous-needlingnad-niogen-stackultra-humancrossfitrowingexercise-protocolpeptide-therapyhormone-optimizationcryotherapyhyperbaric-oxygenred-lightozone-therapyexosomestherapeutic-plasma-exchangebody-compositiongrip-strength

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Educational summary of the cited expert source — not medical advice. Open the source recording linked above and consult a qualified physician before acting on any protocol.