Episode
1 Tbsp Fixes Insulin AND Spikes Testosterone (doctors don't mention this)
~13 min
Episode Brief·YouTube

1 Tbsp Fixes Insulin AND Spikes Testosterone (doctors don't mention this)

Thomas DeLauer

TL;DR

The four things you'd lose by not watching

4 items
1

One to three tablespoons of tahini daily can significantly improve several health markers, including reducing cardiovascular disease risk by 39%, lowering blood glucose, and supporting testosterone levels.

2

Tahini's benefits stem from sesame lignans, which are more bioavailable in ground form, helping to shift estrogen metabolism towards protective pathways and reduce estrogen's drag on testosterone production.

3

When purchasing tahini, prioritize brands that contain only hulled and mashed sesame seeds, possibly with a little sesame or olive oil, and avoid those with added sunflower or canola oils.

4

For optimal benefits, consume tahini with breakfast or earlier in the day, and consider pairing it with cruciferous vegetables for enhanced estrogen modulation or fermented foods to support gut microbiome health, which is crucial for lignan activation.

Protocols

Concrete recipes — what, when, how much, and why

3 items

Daily Tahini Consumption

WhatConsume 1-3 tablespoons of tahini daily.
WhenPreferably with breakfast or earlier in the day, but can also be consumed in the evening.
Dose1-3 tablespoons (28-50 grams)
For whomGeneral population, especially those looking to improve insulin sensitivity, cardiovascular risk markers, and testosterone levels.
WhyTo leverage tahini's benefits for cardiovascular health, blood sugar regulation, and testosterone support.
CaveatsEnsure tahini is pure ground sesame with no added unhealthy oils. Gut microbiome health is crucial for activating lignans.

The speaker recommends a daily intake of 1 to 3 tablespoons of tahini, suggesting that consuming it earlier in the day, particularly with breakfast, might offer additional benefits like appetite suppression throughout the day. However, he also notes that evening consumption, perhaps with dressings or alongside protein, could still be beneficial. The core of the protocol is to ensure the tahini is pure, made from ground sesame seeds, and free from undesirable added oils like sunflower or canola. The speaker emphasizes that the lignans in sesame require gut bacteria for conversion into their active form, meaning a healthy and diverse gut microbiome is essential to maximize the benefits. Therefore, supporting gut health through soluble fiber (veggies) and fermented foods (kefir) is an important adjunct to this protocol. Additionally, pairing tahini with cruciferous vegetables can offer a different, complementary estrogen modulation effect.

Mechanism

Tahini provides bioavailable sesame lignans. These lignans modulate estrogen metabolism, shifting it towards protective metabolites and reducing estrogen's suppressive effect on testosterone. They also contribute to antioxidant activity, improved endothelial function, and reduced triglycerides.

Two to three tablespoons of tahini seemingly taken earlier in the day. That seems to be better, but I don't think it matters too much. I think you generally do want to have it with breakfast because it might have an appetite suppression effect throughout the day, but I could see huge benefits to having in the evening, too.

Also said
So, make sure it's pure ground sesame with no added oils unless it's sesame oil or maybe some olive oil.Crucial quality control for tahini selection.
And remember that the lignans in sesame require gut bacteria to convert into their active form. So, your microbiome health matters.Highlights the importance of gut health for efficacy.

Pairing Tahini with Cruciferous Vegetables

WhatCombine tahini with cruciferous vegetables (e.g., baked cauliflower drizzled with tahini).
For whomIndividuals looking for comprehensive estrogen balance and overall health benefits.
WhyTo achieve a complementary estrogen modulation effect, enhancing the benefits of both foods.

The speaker suggests a synergistic approach by combining tahini with cruciferous vegetables like cauliflower. He specifically mentions 'baked cauliflower drizzled with tahini' as an example. The rationale behind this pairing is that while tahini's lignans influence estrogen metabolism in one way, cruciferous vegetables offer a 'different estrogen modulation effect.' This combination is intended to provide a more comprehensive approach to balancing estrogen metabolites, potentially enhancing the overall health benefits related to hormonal regulation.

Mechanism

Tahini's lignans modulate estrogen metabolism, while cruciferous vegetables contain compounds that also influence estrogen pathways, providing a synergistic effect.

And if you want to hit the estrogen metabolite ratio from the other direction, you can actually pair it with cruciferous vegetables. So, like cauliflower, baked cauliflower drizzled with tahini. This is getting you a different estrogen modulation effect.

Supporting Gut Microbiome for Tahini Efficacy

WhatConsume soluble fiber from vegetables and fermented foods like kefir.
For whomAnyone consuming tahini for its health benefits.
WhyTo ensure a healthy and diverse gut microbiome, which is necessary for converting sesame lignans into their active, beneficial forms.
CaveatsIf gut diversity is compromised, the return from tahini will be diminished.

The speaker explicitly states that the beneficial lignans found in sesame (and thus tahini) are not active in their consumed form but require conversion by gut bacteria. Therefore, maintaining a healthy and diverse gut microbiome is paramount to realizing tahini's full potential. He recommends incorporating soluble fiber from vegetables and fermented foods such as kefir into the diet to support gut health. The implication is that without a robust microbiome, the efficacy of tahini will be significantly reduced, as the active compounds will not be properly formed.

Mechanism

Sesame lignans require gut bacteria for their conversion into active metabolites. A healthy microbiome facilitates this conversion, maximizing the therapeutic effects of tahini.

And remember that the lignans in sesame require gut bacteria to convert into their active form. So, your microbiome health matters. So, veggies when you want soluble fiber, fermented foods, kefir. Okay, because if your gut diversity is compromised, you get less return from the same amount of tahini.

What's new

Personal practice updates, fresh positions, predictions

5 items

Tahini's comprehensive health benefits beyond typical understanding

0:00

Tahini, a simple food, offers a wide array of health benefits, including significant improvements in cardiovascular risk markers, blood glucose, blood pressure, and testosterone support, often overlooked by conventional medical advice.

Why this matters: The speaker emphasizes that these benefits are derived from a common food, contrasting it with the focus on other interventions, and highlights the depth of human trial data supporting its efficacy.

Background

Many common foods are often dismissed as mere calories, but tahini, a staple in the Middle East, possesses potent medicinal properties due to its unique composition.

The speaker introduces tahini as a powerful food, claiming it makes hummus 'look like a flipping joke' due to its profound health impacts. He states that just one tablespoon daily has been shown to drop a cardiovascular disease risk marker by 39% and significantly lower blood glucose within an hour. Furthermore, it supports testosterone through a mechanism often missed by supplements. He plans to cover four human studies demonstrating its effects on testosterone, blood sugar, cardiovascular disease risk, and blood pressure, suggesting that such a simple, tasty, and historically significant food should be a kitchen staple given its proven benefits.

This stuff makes hummus look like a flipping joke. One tablespoon every day and we saw a cardiovascular disease risk marker drop 39%. Blood glucose dropped significantly within an hour and it supports testosterone through a pathway that almost all supplements miss entirely.

Also said
And when you see the human trial data on what it does to blood sugar, to blood pressure, to triglycerides from literally one to two tablespoons at breakfast, you're going to wonder why this isn't in your kitchen already.Highlights the surprising efficacy and the speaker's belief in its underutilization.
It's a food that's been a staple across the Middle East for like ever.Emphasizes its historical and cultural significance as a food, not just a supplement.

Tahini's role in testosterone support via estrogen modulation

1:20

Tahini, through its concentrated sesame lignans, helps support testosterone by reducing the negative impact of estrogen, specifically by shifting estrogen metabolism towards protective metabolites and freeing testosterone from estrogen-mediated suppression.

Why this matters: This mechanism is presented as a unique pathway that many testosterone-boosting supplements overlook, focusing on indirect support rather than direct synthesis.

Background

As men age and body fat increases, the aromatase enzyme converts more testosterone into estradiol, which can then break down into problematic proliferative metabolites, suppressing testosterone production.

The speaker explains that as individuals age and body fat increases, the enzyme aromatase converts more testosterone into estradiol. This estradiol then breaks down into various metabolites, some protective and others proliferative and problematic. Sesame lignans, abundant in tahini, play a crucial role by shifting this pathway, pushing estrogen towards more protective metabolites and away from the negative, proliferative ones. While tahini doesn't directly boost testosterone production, it reduces the 'drag' that estrogen places on testosterone. A study in the World Journal of Men's Health on male rats showed that sesame supplementation increased plasma testosterone in a dose-dependent manner and also increased Leydig cell counts (cells that produce testosterone). The proposed mechanism involves reducing estrogen receptor load and shifting metabolite ratios, thereby partially freeing the testosterone production axis from estrogen-mediated suppression.

Although tahini isn't boosting testosterone directly, it is a concentrated form of sesame and it's reducing the drag that estrogen puts on testosterone production.

Also said
The sesame lignans shift which pathway that estrogen goes down. They actually push more towards the protective metabolite and pull away from the proliferative negative estrogen.Explains the specific mechanism of estrogen modulation.
So, you're like at a core biological level increasing testosterone at a like how the cells that produce it.Highlights the fundamental biological impact on testosterone-producing cells.

Importance of tahini's form for lignan bioavailability

3:00

Tahini is considered the ideal format for consuming sesame lignans because the grinding process breaks down the seed's hull, which otherwise limits the release and absorption of these beneficial compounds from intact sesame seeds.

Why this matters: This emphasizes that the preparation method of a food can significantly impact its nutritional efficacy, making tahini superior to whole sesame seeds for certain benefits.

Background

Whole sesame seeds have a hull that can prevent the full release of lignans, and people often don't chew them thoroughly enough to overcome this barrier.

The speaker argues that tahini is the optimal way to consume sesame for its lignan benefits. He explains that the grinding process involved in making tahini effectively breaks down the seed's hull. This hull, when intact, limits the release of lignans. When consuming whole sesame seeds, such as those on a bun or in a stir-fry, people often don't chew them sufficiently to break down the hull and release the lignans. Tahini, being already pureed, bypasses this issue, ensuring better bioavailability of the active compounds. This pre-mastication by processing makes tahini a more efficient delivery system for the beneficial lignans.

In my opinion, tahini's the ideal format for this because grinding the seed breaks down the hull and that's what limits the lignin release from the intact sesame seeds to begin with.

Also said
You have to chew sesame really well. And a lot of times like sesame's on a bun or it's mixed into stir-fry and you're just kind of inhaling it, sliding it down your throat hole. You're not actually chewing it, breaking it down, and masticating it.Illustrates the common failure to properly process whole sesame seeds.
In this case, tahini, it does the mastication for you. It's already pureed and you can just get the benefit.Highlights the convenience and efficiency of tahini's form.

Tahini's impact on blood sugar and cardiovascular health in diabetics

3:50

Human studies show that tahini significantly lowers post-meal blood glucose, prevents post-meal blood pressure spikes, and offers cardioprotective effects in individuals with type 2 diabetes, making it a valuable dietary intervention.

Why this matters: These findings demonstrate tahini's direct therapeutic potential for managing common metabolic issues in a vulnerable population.

Background

Type 2 diabetics face higher risks of cardiovascular events and often experience post-meal glucose and blood pressure fluctuations.

The speaker details two human studies demonstrating tahini's benefits for blood sugar and cardiovascular health, particularly in diabetics. The first study, in European Food Research and Technology, involved healthy men consuming 50g of tahini, showing significantly lower plasma glucose at one, three, and four hours post-consumption. It also indicated absorption of tahini's antioxidant compounds. A more impactful study in the Journal of Atherosclerosis Prevention and Treatment focused on type 2 diabetics with controlled blood sugar. Participants consumed either bread with tahini or bread with margarine and cheese. While flow-mediated dilation improved in both groups, the tahini group did not experience the post-meal systolic blood pressure increase seen in the control group. Researchers concluded that tahini offers a cardioprotective effect for type 2 diabetics, suggesting it as a superior breakfast or snack option. This is crucial because diabetics have a higher cardiovascular disease risk, and tahini provides both glucose-lowering and cardiovascular protection from a simple food swap.

You're getting glucose lowering effects and cardiovascular protection in an insulin resistant population from a single food swap.

Also said
Plasma glucose was significantly lower at one, three, and four hours after they had the tahini.Provides specific data on blood glucose reduction.
After the tahini, it didn't. Okay, there was no rise. And the researchers concluded that a meal that has tahini exhibits a cardioprotective effect in type two diabetics that makes it a stronger option for breakfast or as a snack.Highlights the prevention of post-meal blood pressure spikes and the cardioprotective conclusion.

Tahini's significant reduction in cardiovascular disease risk markers

8:00

An RCT showed that replacing part of breakfast with two tablespoons of tahini for six weeks led to a 39% reduction in the atherogenic index of plasma, a key composite marker for cardiovascular disease risk, alongside decreases in triglycerides and total cholesterol.

Why this matters: A 39% reduction in a major cardiovascular risk marker from a simple dietary change is a remarkably high impact for a food intervention.

Background

Cardiovascular disease remains a leading health concern, and effective, simple dietary interventions are highly sought after.

The speaker highlights a randomized controlled trial (RCT) published in the Archives of Iranian Medicine, which involved 41 diabetic individuals. One group replaced part of their breakfast with 28g (about two tablespoons) of tahini for six weeks, while the control group maintained their usual breakfast. After six weeks, the tahini group exhibited a substantial decrease in serum triglycerides (15.3 mg/dL). More significantly, their atherogenic index of plasma (AIP), a composite marker for cardiovascular disease risk, dropped by an impressive 39%. Additionally, they saw reductions in total cholesterol and a slight increase in HDL. The speaker expresses frustration that such a simple, tasty, and effective dietary intervention, offering such a significant reduction in a critical risk marker, is not more widely promoted, emphasizing the power of real food beyond just calories.

But the more important finding here was that the atherogenic index of plasma, which is a composite marker for cardiovascular disease, that dropped 39% from literally just tahini with breakfast.

Also said
They dropped 15.3 mg per deciliter.Provides the specific reduction in triglycerides.
And it kind of frustrates me that we still focus on all kinds of other things and we don't tout the benefits of real food. Like food has power. It's not just calories.Conveys the speaker's strong opinion on the underappreciation of food's medicinal properties.

Recommendations

Products, supplements, and tools mentioned in the episode

2 items

Tahini (specific brands)

Product

When selecting tahini, look for brands that contain only hulled and mashed sesame seeds, possibly with a little sesame oil or olive oil. Avoid brands with added sunflower or canola oils.

The speaker strongly advises consumers to scrutinize tahini labels. The ideal tahini should consist solely of hulled and mashed sesame seeds, with the potential addition of a small amount of sesame oil or olive oil to achieve desired consistency. He explicitly warns against tahini products that include sunflower oil or canola oil, stating that these additions 'defeat the purpose' of consuming tahini for its health benefits. He explains that sesame oil itself has a good fatty acid profile due to sesamin and sesamolin, which protect it from oxidation, making it stable for cooking. The emphasis is on purity to ensure the full benefits of the sesame lignans are obtained without counteracting effects from undesirable oils.

vs alternatives

Contrasts pure tahini with brands containing unhealthy added oils like sunflower or canola.

So, with tahini, you need to look at the label. This is so important because tahini should really just be hulled and mashed pureed sesame seeds maybe, just maybe with a little olive oil in it. There are so many brands out there that have sunflower oil added, that have canola oil added. That is defeating the purpose.

Watching the Molasses Video

Practice

Recommended for those interested in other foods that help with insulin resistance, as molasses pairs well with tahini's benefits.

The speaker briefly mentions another food, molasses, that is often overlooked for its benefits in addressing insulin resistance. He refers to a previous video he created specifically on molasses and its effects on insulin resistance. He suggests that the information in that video would complement the discussion on tahini, as molasses 'pairs pretty well' with tahini's benefits. He encourages viewers to watch that video next for additional insights into dietary strategies for insulin resistance.

And there's another food that a lot of people overlook for insulin resistance and that's molasses. I did a video on molasses and its effect on insulin resistance cuz that pairs pretty well. So, you might get something out of that video.

Notable quotes

Lines worth pulling out — contrarian, specific, or perfectly phrased

6 items
This stuff makes hummus look like a flipping joke.
A strong, attention-grabbing opening statement that immediately conveys the speaker's high regard for tahini's benefits.
And when you see the human trial data on what it does to blood sugar, to blood pressure, to triglycerides from literally one to two tablespoons at breakfast, you're going to wonder why this isn't in your kitchen already.
Expresses surprise and frustration at the underutilization of such an effective and simple food, highlighting its proven benefits.
So, although tahini isn't boosting testosterone directly, it is a concentrated form of sesame and it's reducing the drag that estrogen puts on testosterone production.
Clearly articulates the indirect but significant mechanism by which tahini supports testosterone, distinguishing it from direct boosters.
You're getting glucose lowering effects and cardiovascular protection in an insulin resistant population from a single food swap.
Summarizes the dual benefits of tahini for a high-risk population (diabetics) through a simple, accessible dietary change.
And it kind of frustrates me that we still focus on all kinds of other things and we don't tout the benefits of real food. Like food has power. It's not just calories.
A passionate statement reflecting the speaker's philosophy on nutrition and the overlooked potential of whole foods.
And remember that the lignans in sesame require gut bacteria to convert into their active form. So, your microbiome health matters.
Highlights a crucial, often overlooked biological prerequisite for tahini's efficacy, linking gut health to nutrient activation.

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Topics covered

tahini benefitsinsulin sensitivitytestosterone supportestrogen modulationsesame lignansblood glucosecardiovascular disease risktriglyceridesblood pressureendothelial functiontype 2 diabetesaromatase enzymeestradiol metabolitesleydig cell countoxidative stressantioxidantsflow-mediated dilationatherogenic index of plasmadietary interventiontahini selection
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