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Peter Attia

Peter Attia

Core

Longevity Medicine

MD, Johns Hopkins / Stanford / NIH

Longevity is earned decades early: track ApoB below 80, build muscle like your life depends on it, and treat exercise as the most powerful drug medicine ignores.

LongevityMetabolicCardiovascularTraining

Episodes

263 episodes
Building strength and muscle mass: optimize training & nutrition for longevity (AMA #71 rebroadcast)

Building strength and muscle mass: optimize training & nutrition for longevity (AMA #71 rebroadcast)

Jul 6 (1mo ago)

What we really care about is strength. And therefore when we look at measurements of lean muscle... it's strength that is probably much more highly associated with... causally associated with mortality, cardiovascular di

muscle-mass-vs-strengthgrip-strength-mortalityhazard-ratios-longevitycentenarian-decathlonv02-max-all-cause-mortality
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397 - Endometriosis and adenomyosis: diagnosis, fertility, reproductive aging, & emerging treatments

397 - Endometriosis and adenomyosis: diagnosis, fertility, reproductive aging, & emerging treatments

Jun 22 (1mo ago)

The cases that stay with me are not the most complex surgeries, not the difficult IVF cycles. They are those women that cry not from pain, but during the appointment from relief. When I tell them, ‘You are suffering. I k

endometriosisadenomyosisfibroidsretrograde-menstruationprogesterone-resistance
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396 – Breast cancer screening: understanding risk, deciding when to start, and more

396 – Breast cancer screening: understanding risk, deciding when to start, and more

Jun 15 (1mo ago)

The rate of false positives and benign biopsies per exam is actually lowest with annual screening, likely because the radiologist has a more recent image to compare to, making it easier to distinguish cancerous changes f

breast-cancer-screening-guidelinesrisk-assessment-calculatorsmammography-vs-mri-vs-ultrasounddigital-breast-tomosynthesisabbreviated-breast-mri
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395 – Brain lipidology: understanding APOE, cholesterol homeostasis, Alzheimer’s disease, & more

395 – Brain lipidology: understanding APOE, cholesterol homeostasis, Alzheimer’s disease, & more

Jun 9 (2mo ago)

Everybody thinks it's delivering cholesterol to cells almost never because every cell can make all the cholesterol it needs.

peripheral-cholesterol-metabolismlipoprotein-biologyreverse-cholesterol-transportbrain-cholesterol-homeostasisblood-brain-barrier
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378 ‒ Women’s health & performance: how training, nutrition, & hormones interact across life stages

378 ‒ Women’s health & performance: how training, nutrition, & hormones interact across life stages

Jan 5 (7mo ago)

osteoporosis is a childhood disease.

womens-healthexercise-physiologyhormoneslife-stagesbone-health
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375 - The ketogenic diet, ketosis, and hyperbaric oxygen: weight loss, cognition, cancer, and more

375 - The ketogenic diet, ketosis, and hyperbaric oxygen: weight loss, cognition, cancer, and more

Dec 8, 2025 (8mo ago)

The ketogenic diet is indeed a magical diet in the way that uh it remarkably changes our physiology and there's no other diet uh that exists that can for example manage drug resistant seizures and it does that because it

ketogenic dietketosishyperbaric oxygenweight losscognition
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371 – Women’s sexual health: desire, arousal, and orgasms, navigating perimenopause, and more

371 – Women’s sexual health: desire, arousal, and orgasms, navigating perimenopause, and more

Nov 3, 2025 (9mo ago)

If you want to be able to have sex in your marginal decade, you need to have a V2 max of probably about 30 milliliters per kilogram per minute. Why? Because it would be pretty tough to have sex if you were doing it right

sexual healthlongevitycentenarian decathlonsleepcardiovascular health
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360 ‒ How to change your habits: why they form and how to build or break them

360 ‒ How to change your habits: why they form and how to build or break them

Aug 11, 2025 (1y ago)

The problem is negative reinforcement is about 1/20th as effective as positive reinforcement.

habit-loopcue-routine-rewardpositive-reinforcementnegative-reinforcementwillpower-fatigue
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359 ‒ How metabolic and immune system dysfunction drive the aging process, NAD, aging clocks, & more

359 ‒ How metabolic and immune system dysfunction drive the aging process, NAD, aging clocks, & more

Aug 4, 2025 (1y ago)

there are two organs that are rate limiting in terms of your aging and it's the central nervous system and the immune system.

immune-system-agingcentral-nervous-system-agingrate-limiting-organsinflammagingoxidative-stress
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357 ‒ A new era of longevity science: models of aging, rapamycin trials, biological clocks, & more

357 ‒ A new era of longevity science: models of aging, rapamycin trials, biological clocks, & more

Jul 21, 2025 (1y ago)

I think the hallmarks was good because it it it drove interest in the field... but uh it also is misleading because I think the idea that aging is 12 different things and you just need to fix all 12 of them is is complet

aging-modelshallmarks-of-agingnetwork-homeostasislinear-damage-oscillationrapamycin
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Navigating bone health: early life influences & strategies for improvement & injury prevention

Navigating bone health: early life influences & strategies for improvement & injury prevention

Jul 7, 2025 (1y ago)

If you look at a group of people who are 65 years old or older who fracture their hip falling, 25% of those people will be dead in 6 months.

bone-mineral-densityhip-fracture-mortalityosteopenia-osteoporosisdxa-screeningmenopausal-bone-loss
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355 – Skincare strategies, the science of facial aging, and cosmetic-intervention guidance

355 – Skincare strategies, the science of facial aging, and cosmetic-intervention guidance

Jun 30, 2025 (1y ago)

The absolute minimum thing I should use on my skin every day, it would be sunscreen.

sunscreen-mineral-vs-chemicalretinoids-retinol-retinaldehyde-tretinoinvitamin-c-serum-stabilityfacial-aging-fat-atrophy-bone-lossevolutionary-beauty-symmetry-proportion
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354 – What the dying can teach us about living well: lessons on life and reflections on mortality

354 – What the dying can teach us about living well: lessons on life and reflections on mortality

Jun 23, 2025 (1y ago)

Bodies die, living things die. It's uh I think a lot of us absorb a notion of death that it's some foreign invader or something that comes out of the woods and grabs us and otherwise I was just fine and then not. Um no.

death-acceptancepalliative-care-vs-hospiceadvance-directivesopioid-mythsdelirium-end-of-life
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352 ‒ Female fertility: reproductive health, treating infertility & PCOS, and the IVF process

352 ‒ Female fertility: reproductive health, treating infertility & PCOS, and the IVF process

Jun 9, 2025 (1y ago)

The most eggs you'll ever have is when you're in your mom's womb as a fetus. And by the time you're born, there's about two million or so eggs. And by the time you start menstruating, you're down to maybe 400,000 or so.

female reproductive biologyovarian reservefollicle selectionaneuploidymiscarriage causes
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351 ‒ Male fertility: optimizing reproductive health, treating infertility, & navigating TRT

351 ‒ Male fertility: optimizing reproductive health, treating infertility, & navigating TRT

Jun 2, 2025 (1y ago)

If you asked me what's the theme for today, I'd say sperm matter a lot.

sperm-journeyspermatogenesisepididymisinfertility-definitionsemen-analysis
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350 ‒ Injury prevention, recovery, and performance optimization for every decade

350 ‒ Injury prevention, recovery, and performance optimization for every decade

May 26, 2025 (1y ago)

The magic word of capacity is what it's all about. Are you building me back to what I want to do?

injury-preventionrehabprehabshoulder-surgerycentenarian-decathlon
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348 ‒ Women’s sexual health, menopause, and hormone replacement therapy (HRT)

348 ‒ Women’s sexual health, menopause, and hormone replacement therapy (HRT)

May 12, 2025 (1y ago)

If a penis shriveled up at age 52, we'd probably have a vaccine sponsored by Pfizer.

menopause-physiologyperimenopausehormone-replacement-therapywomen-health-initiativetestosterone-women
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Peter's takeaways on sleep, chronic pain, cancer drugs, AI in healthcare, & more (PS 5 sneak peek)

Peter's takeaways on sleep, chronic pain, cancer drugs, AI in healthcare, & more (PS 5 sneak peek)

May 5, 2025 (1y ago)

Trauma is a moment of perceived helplessness that activates the limbic system... the sine qua non of trauma is that there's a disconnected version of a person that shows up to life, relying on maladaptive strategies to r

traumamaladaptive-copingtrauma-tree-modelguilt-vs-shameimplicit-vs-explicit-memory
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346 - Scaling biotech and improving global health: lessons from an extraordinary career in medicine

346 - Scaling biotech and improving global health: lessons from an extraordinary career in medicine

Apr 28, 2025 (1y ago)

I believe deep down it was an enormous mistake to be the head of science to be the head of advocacy. I think having having Dr. Fouchy as being both of those hats was a cataclysmic error. No. And it's not about him. No hu

science-advocacyivermectin-cancerprostate-cancer-screeningai-clinical-trialsliquid-biopsies
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345 ‒ Chronic pain: pathways, treatment, and the path to physical and psychological recovery

345 ‒ Chronic pain: pathways, treatment, and the path to physical and psychological recovery

Apr 21, 2025 (1y ago)

Pain is the great motivator. Pain is one of the most primitive experiences going back to, if you will, single cell organisms. ... pain is so wonderful because it's so terrible. It keeps us alive.

pain-definitionnociception-vs-painbiopsychosocial-modelpain-typesfibromyalgia
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